IBD Flashcards

1
Q

UC stools can be?

A

• blood & mucous in stool

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2
Q

CD stool?

A

dark colour - bleed in proximal bowel

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3
Q

Cramping before stool in CD?

A

abdominal pain
abdominal mass

UC: Cramping pain before passing stool.
No abdominal mass.

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4
Q

Severe UC symptoms

A
  • tachycardia >90bpm

* temp >37.8ºC

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5
Q

Site of UC

A
  • Colon
  • continuos mucosal inflammation/ surface
  • rectum
  • extends promiximally
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6
Q

Site of CD

A
  • GIT mouth to anus
  • commonly illeocaecal/ terminal ileum & proximal colon
  • transmural - through gut wall
  • fibrosis
  • strictures causing obstruction & fistulae
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7
Q

IBD tests

A
  • Hb - less, GI inflammation
  • WBC - high, infection
  • Platelets - high
  • Ferritin -
  • CRP or ESR - high, GI inflammation
  • Albumin - less, GI inflammation, malabsorption
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8
Q

IBD other tests

A
  • K - less, diarrhoea
  • Na+ - less, diarrhoea
  • Cr raised - dehydration
  • Urea - high, dehydration
  • Mg - low, diarrhoea
  • LFT - high, sepsis
  • VitB12 - less,
  • VitD - less, poor bone health/recurrent corticosteroid
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9
Q

IBD tender, red patches on both shin

A
  • Erythema nodosum
  • can be w. joint pain/swelling and fever
  • IBD complication.
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10
Q

Extraintestinal complication of UC

A
  • Joints – ankylosing spondylitis, arthritis
  • Skin – pyoderma gangrenosum
  • Eye – uveitis
  • Bone – osteoporosis
  • Liver and biliary tree
  • Malnutrition – kg loss, anaemia, vitamins (all more common in CD as it involves small intestine)
  • Thromboembolic risk – needs VTE prophylaxis
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11
Q

reduced vitamin C, Ca, Mg

A

scurvy

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12
Q

Malnutrition - reduced Zinc =

A

taste impaired

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13
Q

Malnutrition - reduced VitB12 =

A

anaemia

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14
Q

Malnutrition - reduced Folate =

A

anaemia

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15
Q

Malnutrition - reduced Fe =

A

anaemia

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16
Q

reduced VitK =

A

bruises, less clotting factor.

17
Q

Severe UC treatment NICE

A
  • IV hydrocortisone 100mg TDS/QDS
  • OR methylprednisolone 60mg OD
  • for 5 days
  • expect results by day 3
  • convert to oral 40mg OD & reduce over 4-6wks.
  • tailor to pt severity & tolerance
  • consider ciclosporin/surgery if no improvement in 72 hrs.
  • Infliximab if CI
18
Q

Factors affect choice & route of UC therapy

A
  • site
  • extent
  • treatment history
  • compliance
  • preparations
  • pt choice
  • risk factors
  • cost
  • allergies
19
Q

proctisis give?

A
  • suppositories.

* Topical mesalazine

20
Q

Topical mesalazine administration in UC

A
  • water based lubricant
  • bedtime to reduce leakage & increase contact time
  • try not to go toilet
  • if it comes out by 10min, insert another
  • stay in position
21
Q

Aminosalicylate therapy formulation of methasalazine tablet - UC

A
  • coated with pH dependent acrylic resin
  • Octasa - Eudragit S, pH>7 dissolves, ileum/colon
  • Solfalk - Eudragit L, pH>6, jejunum & ileum to colon
22
Q

Formulation of mesalazine granules - UC

A

• ethylcellulose coated

23
Q

Maintenance therapy for UC on top of mesalazine

A
  • azathioprine 2-2.5mg/kg/OD

* mercaptopurine 1-1.5mg/kg/OD

24
Q

Mercaptopurine metabolism ?

A
  • TUA/ thiouric acid
  • xanthine oxidase
  • excreted
  • MeMP/ methylmercaptopurine
  • methylation by TPMT/ thiopurine S-methyltransferase
  • TIMP/ thioinosine monophosphate
  • catalysis by HPRT/ hypoxanthine phosphoribosyltransferase
25
Q

From TIMP then? in mercaptopurine metabolism

A
  • TGMP/ thioguanine monophosphate
  • metabolised by IMPDH
  • kinases convert TGMP into TGM/ thioguanine nucleotides
26
Q

UC tests when presented

A
  • stool culture
  • bloods - FBC, U&E, LFTs, C reactive protein
  • Endoscopy
  • Colonoscopy
27
Q

UC symptoms

A
  • Tenesmus
  • kg loss less common than CD
  • mucus in stools
  • fever
  • urgency
  • abdominal pain & cramps
  • bloody diarrhoea
  • malnutrition less common than CD
28
Q

UC red flags

A
  • Venous thromboembolism
  • Toxic megacolon - risk of perforation = surgical emergency
  • secondary osteoporosis - assess fracture risk
  • colorectal cancer risk
29
Q

Oral mesalazine coated in?

A

Eudragit S to reach colon

30
Q

UC first line?

A

5-ASA

Aminosalicylates mono therapy oral eg
Mesalazine, sulfasalazine