IBS Flashcards

1
Q

what does IBS stand for?

A

Irritable Bowel Syndrome

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2
Q

how long must you have symptoms of IBS before we can say it is IBS?

A

6 months

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3
Q

what makes abdo pain better in IBS?

- this is a requirement for it to be diagnosed as IBS

A

pain relieved by defecating

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4
Q

which age group is most at risk?

A

20-30

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5
Q

which gender is most at risk?

A

female

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6
Q

what happens to prevalence with age?

A

decreases

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7
Q

what foods/drinks can increase risk?

-give 4

A

alcohol
caffeine
spicy
fatty foods

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8
Q

which drug group commonly causes IBS?

A

antibiotics

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9
Q

what are the risk factors for IBS?

-7

A
GI infection 
GI inflammation 
diet 
psychosocial factors 
drugs
younger age group 
female
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10
Q

how many people have their symptoms triggered by foods?

% wise

A

90%

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11
Q

what psychosocial factors can increase risk?

A

stress
anxiety
depression

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12
Q

what are the differentials?

- give 4

A

crohn’s
coeliac
cancer
UC

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13
Q

complications of IBS?

-2

A

depression, anxiety

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14
Q

does acupuncture help IBS?

A

no

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15
Q

pt has typical IBS Hx, but also has rectal bleeding.

what should be a differential now?
-2

A

cancer

UC

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16
Q

pt has typical IBS Hx, but also has weight loss.

what should be a differential now?
-3

A

crohn’s
coeliac
cancer

17
Q

pt has typical IBS Hx, but these symptoms have started now at 68 years of age.

what should be a differential now?

18
Q

pt has typical IBS Hx, but also has a FHx of cancer.

what should be a differential now?

19
Q

what are the ABC symptoms of IBS?

A

Abdo pain
Bloating
Change in bowel habit (diarrhoea/constipation)

20
Q

how long you do need the ABC symptoms of IBS before we can consider a diagnosis?

21
Q

can you get mucus in stool in IBS?

22
Q

can you get blood in stool in IBS?

A

no

must be a different condition then

23
Q

what type of diagnosis is IBS?

A

diagnosis of exclusion

24
Q

what blood tests did NICE say you can use to exclude differentials?
-4

A

FBC
ESR, CRP
Coeliac serology

25
pt has just been diagnosed with IBS. diarrhoea is main symptom. what OTC can they try to help this? how long for?
probiotics | 4 weeks
26
pt has just been diagnosed with IBS. constipation is main symptom. what lifestyle change can they try to help this?
high fibre diet
27
is exercise recommended?
yes
28
what is the 1st line Mx?
change lifestyle factors
29
what is general diet advice? | -7
``` Eat regular don’t skip meals, drink water oats are good. No processed foods. Only 3 pieces of fruit/day. Less tea & coffee. ```
30
1st line Mx for diarrhoea failed. What drug can be given now?
loperamide
31
1st line Mx for constipation failed. What class of drug can be given now? give an example of this class?
bulk forming laxative fybogel
32
IBS pt has refractory constipation. what drug can you try now? which messenger molecule is upregulated by this drug? how does this help constipation?
linaclotide ↑cGMP stimulates water, Cl- & HCO3- secretion into intestine lumen
33
IBS pt has refractory abdo pain. what is the 1st drug you should try?
amitriptyline
34
all lifestyle factors and drug options have been exhausted. symptoms still there. who can GP refer to now? - 3 specialties
Refer to gastroenterologist Refer to dietician Refer to psychiatrist
35
moa of loperamide? on which receptors in what plexus does it act? which specific organ does it act in?
opioid-receptor agonist μ-opioid receptors in the myenteric plexus large intestine
36
moa of loperamide? how exactly does loperamide help diarrhoea?
↓tone of smooth muscle in LI --> ∴food stays longer in LI --> more water absorbed from food into blood.
37
main effect of loperamide?
stops diarrhoea