ICP - intrahepatic cholestasis of pregnancy

Question 1

define ICP

Answer 1

multi-factorial condition characterised by itching without a rash and abnormal liver function blood tests
itching in pregnancy affects 25% of women but ICP affetcs 0.7%
higher rates seen in women with indian pakistani and chilean heritage (RCOG, 2022)

Question 2

how does ICP develop

Answer 2

in late 2nd and 3rd trimester, then resolves after birth of placenta
more common during winter months
multiple pregnancy
older maternal age
family and personal history of obstetric cholestasis

Question 3

symptoms of ICP

Answer 3

intense itching without a rash usually hands and feet
jaundice, pale stools, dark urine, right upper quadrant pain, tiredness

Question 4

antenatal care: screnning for ICP

Answer 4

blood tests: serum bile acids, LFTs
ask about presence of itching: location, rash, risk factors and symptoms associated with ICP