II - Acute and Chronic Inflammation Flashcards Preview

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Flashcards in II - Acute and Chronic Inflammation Deck (67)
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2

It is a protective response intended to eliminate the initial cause of cell injury as well as the necrotic cells and tissues resulting from the original insult.

Inflammation(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.31

3

Inflammation which is characterized by plasma protein exudation and a predominantly neutrophilic leukocyte accumulation.

Acute inflammation(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.32

4

Inflammation typified by influx of lymphocytes and macrophages associated with vascular proliferation and fibrosis.

Chronic inflammation(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.32

5

Five cardinal signs of inflammation?

Heat (calor)redness (rubor)swelling (tumor)pain (dolor)loss of function (functio laesa)(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.32

6

Initial vascular response to injury?

Vasoconstriction.(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.33

7

An ultrafiltrate of blood which contains little protein. Results from arteriolar vasodilation and increased blood flow.

Transudate(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.34

8

Results from increased vascular permeability, leading to leakage of protein into tissues.

Exudate(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.34

9

Fluid accumulation in extravascular space.

Edema(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.34

10

State the molecule in the endothelium responsible for this stage of vascular inflammatory response:Rolling

Selectins(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.36

11

State the molecule in the lymphocyte responsible for this stage of vascular inflammatory response:Firm adhesion

Integrins(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.37

12

State the molecule in the endothelium responsible for this stage of vascular inflammatory response:Transmigration

PECAM-1/CD 31(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.37

13

State the endothelial adhesion molecule responsible for this stage of vascular inflammatory response:Intercellular adhesion

ICAM -1(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.37

14

State the lymphocytic adhesion molecule counterpart of the following endothelial receptors:E-Selectin

Sialyl-Lewis X modified glycoprotein(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.36

15

State the lymphocytic adhesion molecule counterpart of the following endothelial receptors:P-Selectin

Sialyl-Lewis X-Modified glycoprotein(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.36

16

State the lymphocytic adhesion molecule counterpart of the following endothelial receptors:ICAM-1

Integrins(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.37

17

State the lymphocytic adhesion molecule counterpart of the following endothelial receptors:CD-31

CD-31(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.37

18

The process of luekocyte accumulation at the periphery of blood vessels is called ______.

Margination(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.36

19

Arrange the following steps in the inflammatory response:A. Recruitment of leukocytesB. Regulation of responseC. Recognition of injurious agentD. Removal of agentE. Resolution

C, A, D, B, E(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.35

20

Arrage the steps in leukocyte recruitment:A. TransmigrationB. Rolling C. MarginationD. Firm adhesion

C, B, D, A(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.35

21

Process of coating microorganisms with proteins that facilitate phagocytosis.

Opsonization(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.38

22

A lymphocyte with ingested microorganism fused with lysosome is called _______.

Phagolysosome(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.39

23

The most important lysosomal enzyme involved in bacterial killing.

Elastase(TOPNOTCH)

24

Process of leukocyte migration toward sites of infection or injury along a chemical gradient.

Chemotaxis(TOPNOTCH)

25

The most important lysosomal enzyme involved in bacterial killing.

Elastase(TOPNOTCH)

26

A peptide Leukocyte granule constituent which kills microbes by creating holes in their membranes.

Defensins(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.40

27

Predominant form of leukocyte during the first 6 - 24 hours of inflammation?

Neutrophils(TOPNOTCH)

28

Predominant form of leukocyte during 24-48 hrs after the onset of inflammation?

Monocytes(TOPNOTCH)

29

Substances responsible for leukocyte-induced tissue injury?

Lysosomal enzymes, reactive oxygen and nitrogen species.(TOPNOTCH)

30

Defective synthesis of CD 18 B-subunit of leukocyte integrins LFA-1 and Mac-1 leading to impaired leukocyte adhesion and migration through endothelium.

Leukocyte adhesion deficiency type 1(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.41

31

Caused by a defect in fucose metabolism resulting in absence of sialyl-lewis X, the oligosaccharide on leukocytes that binds to selectins on activated endothelium.

Leukocyte adhesion deficiency type 2(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.41