Immune part II Flashcards
(32 cards)
TACO(Transfusion-Associated circulatory overload
rapid plasma volume expansion
mostly seen in elderly with heart problem
Febrile non-hemolytic transfusion reaction treatment?
Hemolytic Transfusion reaction due to? Treatment?
treat with Acetaminophen (Coombs Neg)
ABO incompatibility (Coombs pos)
Stop transfusion and IV fluid
Both pre-form antibodies
HS? Antibody binds to FAB region of IgE on Mass cell causing degranulation
hypersensitivity 1
anaphylaxis
HS? Pernicious anemia, HIT, Rheumatic fever, M. Gravis
Bullus pemp. Hashimoto and Grave are examples of?
Type 2 HS
Antibody production against cells, tissues, receptor
Antibody-antigen complex and deposit EG:
PSGN
SLE
Arthus reaction
serum sickness
Polyarteritis nodosa
PPD, contact dermatitis, Graft vs. host dz
CD 4/8 T cell involved HS 4
Kill Vaccine ( A TRIPP could Kill you), causes humoral response MHC II
Hep A, Typhoid (IM), Rabies, Influenza (IM), Polio(Salk IM), Pertussis KILL
HPV: human papilloma V, HBV: Hepatitis B v. vaccines are
Recombinant
Diphtheria, tetanus vaccines are
Toxoid
MMR and varicella vaccines are given to HIV pt CD4 count
CD4 count above 200
Live-attenuated vaccines
My TRIP on Yellow Van
Yellow fever
varicella
rotavirus(oral
Influenza(intranasal)
Polio(sabin,oral)
MMR,
Typhoid (oral)
DX of Acute promyelocytic Leukemia: functional pancytopenia and
DX confirms with…
Auer rods: Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblast
fluorescent insiti hybridization(FISH)
What Duchene MD,
ornithine transcarbamylase def and
Fabry have in common
X-Linked
worse symptoms with Turner syndrome
Wiskott-Aldrich syndrome,
Ocular Albinism,
G6PD inheritance
x-linked
Becker MD,
Hemophilia A/B,
Lesch-Nyah,
Hunter syndrome,
Bruton X-LA
X-linked
which inheritance pattern will leave pt with Turner syndrome more susceptible than 46 XX,
Turner: monosomy X(45,X)
Comorbidity with any X-linked is problematic
colon cancer with numerous adenomatous polyps has a tumor suppressor gene?
genetic change affecting APC?
Mutation in KRAS and APC: increase cell entering S Phase
Proto-oncogenes: deletion or loss of function mutation leads to cancer
neonate with cataracts, PDA, thrombocytopenia purpura, sensory neural defects, large liver&spleen. preventions
Congenital rubella syndrome
live attenuated vaccine
57M + large nest mass, mix inflammatory cellularity with some large cells showing bilobed nucleus? CD marker?
Reed-Sternberg cell
CD 15/30
Hodgkin disease
Positive skew
neg skew
median represent the central tendency
mean>median
mean<median
elevated carnitine ester strongly suggests a defect in
Occurs in Mito matrix
fatty acid oxidation early step
Enzyme: VLCAD(very long-chain acyl-CoA dehydrogenase def
low carnitine ester in muscle and serum
primary carnitine defi
carnitine transporter
4M +fever, rash, urticaria, with hand, wrist, and knee pain. 10dy HT or URT infection. Treatment
Serum sickness reaction HS type 3
Treat with Anhihistamines & steroid
blue-green pigmented growth with a fruity smell
Exotoxin A
similar to?
P. Aeruginosa: G(-) oxidase-pos, aerobic rod, cat pos
stops EF-2 :protein synthesis
diphtheria
