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Immune part II Flashcards

1
Q

TACO(Transfusion-Associated circulatory overload

A

rapid plasma volume expansion
mostly seen in elderly with heart problem

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2
Q

Febrile non-hemolytic transfusion reaction treatment?

Hemolytic Transfusion reaction due to? Treatment?

A

treat with Acetaminophen (Coombs Neg)

ABO incompatibility (Coombs pos)
Stop transfusion and IV fluid

Both pre-form antibodies

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3
Q

HS? Antibody binds to FAB region of IgE on Mass cell causing degranulation

A

hypersensitivity 1
anaphylaxis

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4
Q

HS? Pernicious anemia, HIT, Rheumatic fever, M. Gravis
Bullus pemp. Hashimoto and Grave are examples of?

A

Type 2 HS

Antibody production against cells, tissues, receptor

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5
Q

Antibody-antigen complex and deposit EG:

A

PSGN
SLE
Arthus reaction
serum sickness
Polyarteritis nodosa

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6
Q

PPD, contact dermatitis, Graft vs. host dz

A

CD 4/8 T cell involved HS 4

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7
Q

Kill Vaccine ( A TRIPP could Kill you), causes humoral response MHC II

A

Hep A, Typhoid (IM), Rabies, Influenza (IM), Polio(Salk IM), Pertussis KILL

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8
Q

HPV: human papilloma V, HBV: Hepatitis B v. vaccines are

A

Recombinant

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9
Q

Diphtheria, tetanus vaccines are

A

Toxoid

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10
Q

MMR and varicella vaccines are given to HIV pt CD4 count

A

CD4 count above 200

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11
Q

Live-attenuated vaccines
My TRIP on Yellow Van

A

Yellow fever
varicella
rotavirus(oral
Influenza(intranasal)
Polio(sabin,oral)
MMR,
Typhoid (oral)

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12
Q

DX of Acute promyelocytic Leukemia: functional pancytopenia and

DX confirms with…

A

Auer rods: Azurophilic peroxidase-positive granular inclusions in granulocytes and myeloblast

fluorescent insiti hybridization(FISH)

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13
Q

What Duchene MD,
ornithine transcarbamylase def and
Fabry have in common

A

X-Linked

worse symptoms with Turner syndrome

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14
Q

Wiskott-Aldrich syndrome,
Ocular Albinism,
G6PD inheritance

A

x-linked

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15
Q

Becker MD,
Hemophilia A/B,
Lesch-Nyah,
Hunter syndrome,
Bruton X-LA

A

X-linked

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16
Q

which inheritance pattern will leave pt with Turner syndrome more susceptible than 46 XX,

A

Turner: monosomy X(45,X)
Comorbidity with any X-linked is problematic

17
Q

colon cancer with numerous adenomatous polyps has a tumor suppressor gene?

genetic change affecting APC?

A

Mutation in KRAS and APC: increase cell entering S Phase

Proto-oncogenes: deletion or loss of function mutation leads to cancer

18
Q

neonate with cataracts, PDA, thrombocytopenia purpura, sensory neural defects, large liver&spleen. preventions

A

Congenital rubella syndrome
live attenuated vaccine

19
Q

57M + large nest mass, mix inflammatory cellularity with some large cells showing bilobed nucleus? CD marker?

A

Reed-Sternberg cell
CD 15/30
Hodgkin disease

20
Q

Positive skew
neg skew

median represent the central tendency

A

mean>median
mean<median

21
Q

elevated carnitine ester strongly suggests a defect in
Occurs in Mito matrix

A

fatty acid oxidation early step

Enzyme: VLCAD(very long-chain acyl-CoA dehydrogenase def

22
Q

low carnitine ester in muscle and serum

A

primary carnitine defi
carnitine transporter

23
Q

4M +fever, rash, urticaria, with hand, wrist, and knee pain. 10dy HT or URT infection. Treatment

A

Serum sickness reaction HS type 3
Treat with Anhihistamines & steroid

24
Q

blue-green pigmented growth with a fruity smell

Exotoxin A

similar to?

A

P. Aeruginosa: G(-) oxidase-pos, aerobic rod, cat pos

stops EF-2 :protein synthesis

diphtheria

25
Q

inguinal hernia strangulation caused by?
PE may show a reducible mass in the scrotum.

A

compromised vascular supply of bowel

26
Q

HIT type 2 caused by antibody against heparin bound to platelet factor 4(PF4) treatment

A

Bivalirudin: direct thrombin inhibitor

27
Q

direct hernia emerges through

A

the posterior wall of the inguinal canal
medial to inferior epigastric vessels
superior to the inguinal ligament
lateral to rectus abdominis

28
Q

pleomorphic clear cells with cytoplasmic vacuoles, scallop nucleus with pos oil Red O stain

A

Liposarcoma

29
Q

flagellated, encapsulated, gram neg rod producing HS
osteomyelitis in sickle cell pt

A

salmonella

30
Q

rotavirus in HIV infected pt presents with

A

mono-like :fever sore throat, large lymph, spleen and liver

31
Q

Lambert-Eaton affects

A

voltage-gated ion channels Ca2+
presynaptic

32
Q

Erythema infectiosum (slapped cheek) + sickle cell =

A

aplastic crisis
B-19

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