Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Random > Immuno > Flashcards

Immuno Flashcards

(100 cards)

Start Studying
1
Q

Bortezomib

A

proteasome inhibitor that dec ability of MHC 1 to present antigen to CD8

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

associated with beta 2 micro globulin and TAP protein

A

MCH1

TAP mutation affects T and B cell

Antigens (peptides, lipids, or polysaccharides) are transported to the RER via transporters associated with antigen processing (TAPs).

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

intracellular pathogen presentation: viruses and some bacteria present on MHC?

A

MHC 1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

following the release of invariant chain with acidified endosome: MHC?

A

MHC II: antigen-presenting cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

the function of CD 16 on NK cells

A

antibody-dependent cell-mediated cytotoxicity
Binds FC region of antibody

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

target down regulated MHC I on all nucleated cells

stimulated by:

A

NK cell

Kill infected cells and tumor cell

stimulated by IL-12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how does NK cell cause apoptosis

A

cross-linking of CD16 causing the release of granzymes, granulysin and performs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

enable increase antibody specificity for antigen

A

somatic hypermutation and affinity maturation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Main cell of humoral immunity

proliferates and differentiate in what areas

A

B cell

germinal centers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

B cell is APC (phagocytic cell) T/F

A

True

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

similar function as CD16 Cell

A

CD 8: intracellular killer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

cytotoxic T cell is activated by

A

binding T cell Receptors to MHC I, release granzymes, granulysin, and perforin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

CD4 T cell= Th0

Differentiate into

A

upstream

Th1 : primarily activates macrophages
and

Th2: primarily stimulates B cells, and enables antibody production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Naive T cell marker

A

CD28
CD4/8
TCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Nucleated/APC marker

A

B7 (-1/-2) CD80/86.
Binds CD28 ( 2nd signal)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Th0 –> Th1
(+)/(-)

A

(+) IL-12/IFN-y–> activate macrophages (macrophages also secreted IL-12)

(-) IL-4/IL10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Th0–>Th2
(+)/(-)

A

(+) IL4/IL10 (activate B cells to become plasma cell–>antibodies to kill extracellular pathogens

(-) IL-12/IFN-y

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Th0–> Treg(+)

A

(+) TGF-Beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Th0–>Th17 (+)

A

(+) IL-6/TGF-Beta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

cells found in granuloma/chronic inflammation

A

Macrophages: histiocytes or epitheloid macrophages

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

How does Th2 activate B Cell

A

CD40 Ligand binds B cell CD40 facilitates differentiation: humor immunity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

early process of T/B cell maturation generating antibodies and TCR with divers combinations, specificities and affinities

A

V(D)J recombination

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

B cells increase specificity antibodies

A

somatic hypermutation/affinity maturation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

location: CD4/8 positive selection: T cell reg. self

A

Thymic cortex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Thymic medulla: T cell the reg. self dies
Negative selection of cd4 and CD 8 autoimmune checkpoint
26
IgA deficiency and Bruton X-linked Agamma
deficiency of humoral immunity
27
congenital Toxo lab. which Ig is pos and why.
IgM because it is the initial response to infection
28
defective CD40 Ligand
Hyper-IgM no B cell somatic hypermutation/affinity maturation Plasma cell stuck in IgM
29
Most abundant AB, responsible for hemolytic dz
IgG 2nd immune response use in passive immunity Eg: RhoGAM, HepB/VZV IVIg
30
Most common hereditary Immunodeficiency mc mucosal AB in mucosal secretions
IgA: atopy: seasonal allergies, asthma, eczema
31
located on surfaces of mast cells, kill parasites
IGE
32
IG associated with allergies and eosinophilia
IGE Eosinophils secrete Major basic protein
33
Hyper Ige (FATED)
Abnormal Face, Abscesses (Staph), retained deciduous Teeth, hyper IgE, Derma findings(eczematoid skin lesion
34
Post-exposure IVIG examples of passive immunity
Hep B VZV tetanus, botulism, diphtheria rabies IgA in breast milk transplacental IgG
35
immune system two major opsonins
C3b and IgG
36
completely depleted in PSGN and SLE flares
C3
37
anaphylatoxins, degranulation of mast cells
C3,C4,C5 (a)
38
Neutrophilic chemotactic molecule
C5a (as with IL8, LTB-4, kallikrein, Platelet-activating factor and PAMPs
39
MAC defi/ C3b deficiency
Gonococcal and meningococcal(Neisseria)
40
hereditary angioedema associated with facial edema, colicky abdominal pain inspiratory stridor, angioedema of extremity and trunk
C1 esterase inhibitor deficiency Bradykinin-mediated
41
Paroxysmal nocturnal hemoglobinuria: complement-mediated RBC lysis
defective GPI anchors: CD55 and CD59
42
Thymus-independent
No T cell response
43
How to elicit T cell response to thymus-independent antigens
conjugation to a protein
44
Examples of conjugate vaccines for thymus-independent immune response
H. Flu type B Strep Pneumo N. Meningitides Typhoid (salmonella typhi)
45
Is toxoid a Thymus-independent?
No. Toxoid is an inactivated toxin that is a protein Eg: Diphtheria and tetanus
46
Thymus-independent response involves
B cell receptor MHC II to Th2 cells There is no memory
47
Macrophages secrete
TNF-a, IL-1 IL-6, IL-8, IL-12
48
T cell Stimulator
IL-2
49
cytokines associated with sepsis
TNF-a: Low BP and cachexia factor in malignancy and IL-1 fever; (Macrophages)
50
IL-8
Neutrophilic chemotactic molecule
51
Osteoclasti-activating factor in lytic bone lesions
IL-1
52
target for fever with NSAID
prostaglandins
53
Dec transcription of IL 2 by inhibiting calcineurin
cyclosporin and tacrolimus
54
sirolimus MOA
dec IL-2 responsiveness
55
Aldesleukin use in RCC and mets melanoma to
increase T cell response increase IL-2
56
defective IL3
affects myeloid cell line GMCSF: sargramostim Treat neutropenia
57
IL-5
stimulates eosinophil maturation IL-5 antagonist Mepolizumab reslizumab Benralizumab
58
Stimulates acute phase protein in liver (CRP, hepcidin)
IL-6 Anti IL-6 in RA: Tocilizumab
59
support humoral immunity, suppress TH1, increase CD4 activation of B cell
IL-4
60
IL-10
anti-inflammatory like IL 4
61
cytokines that stimulate platelets
IL-11 Oprelvekin used post chemo
62
IFN beta treats
treats Multiple sclerosis (acute flares use steroids )
63
CD 15/30 on a large bilobed cell with abundant cytoplasm?
Reed-Sternberg cells in Hodgkin disease
64
Marker seen in CLL
CD 5/23
65
Macrophages TLR4 binds to LPS endotoxin
CD14
66
CD 16/56
NK: 56 more specific 16 binds Fc region of IgG
67
LAF-1 interin
CD18
68
EBV uses _______ to invade B cell
CD19/20/21
69
CD 80/86
B7 -1/7-2 binds CD28 on T cell
70
CD found on B cell and macrophages activated by CD40L
CD40
71
anti body associated with recurrent miscarriage
antiphospholipid
72
Antiphospholipid syndrome associated antibodies
anti-beta 2 microglobulin anti-cardiolipin lupus anticoagulant may show false-pos in syphilis screening in pt with SLE
73
Anti-hemidesmosome anti-desmosome(anti-desmoglein 1/3)
Bullous Pemp (linear deposit on IF) Pemp Vulgaris(net-like deposit on IF)
74
Anti-GBM(Anti-collagen IV linear IF
Goodpasture syndrome
75
Mutation in collagen IV affecting lungs and kidneys
Alport syndrome
76
Anti proteinase 3, C-ANCA seen with Pauci-immune glomerulonephritis
Granulomatosis with polyangiitis cough, dyspnea, hemoptysis chronic ENT involvement rapidly progressive (crescentic) glomerulonephritis (RPGN)
77
necrotizing granulomatous vasculitis with eosinophilia Eosinophilic Granulomatosis with polyangiitis presents with
MPO-ANCA/pANCA Severe allergic asthma attacks (chief complaint) Allergic rhinitis/sinusitis Skin nodules, palpable purpura Pauci-immune glomerulonephritis
78
microscopic polyangiitis Pauci-immune glomerulonephritis
anti-Myeloperoxidase palpable purpura No granuloma
79
SLE thrombocytopenia/aplastic anemia due to
increase peripheral destruction (ABs destruction)
80
Anti-smith (ribonucleoprotein)
SLE
81
SLE antibodies
anti-double-stranded DNA, anti-hematologic cell line (leading to aplastic anemia) Anti-Smith (more specific)
82
Anti-histone Drugs?
Drug-induces SLE MOM is HIP Minocycline Hydralazine INH Procainamide penicilamine
83
Anti-post-synaptic acetylcholine receptor (thymoma) anti-presynaptic voltage-gated calcium channel (small cell lung cancer)
M. gravis Lambert-Eaton
84
what antibody in Ovarian cancer is associated with Polymyositis/Dermatomyositis
Anti-Jo1 (Antisynthetase syndrome) Anti mi-2 (helices)
85
Scleroderma Limited Diffused
Anti- centromere Anti-topoisomerase I (Scl-70)
86
Anti-mitochondrial
Primary biliary cirrhosis
87
Anti-CCP(Cyclic citrullinated peptide)
Specific for RA
88
Anti-SS-A(anti-Ro) Anti-SS-B(anti-la)
Sjogren syndrome
89
Anti-TSH (thyroid stimulating immunoglobulin
Graves hyperthyroidism
90
Hashimoto thyroiditis transient hyper to late hypothyroidism
Pregnancy Anti-thyroperoxidase(anti-microsomal Anti-thyroglobulin
91
Diffuse lymphocytic infiltration (cytotoxic T lymphocytes) with germinal center HLA association
T cell and B cell Hashimoto Associations with HLA-DR3, and DR5
92
Anti-gliadin, anti-tissue transglutaminase IgA
Celiac Dz
93
Anti zinc transporter 8, anti-glutamic acid decarboxylase
DM type 1
94
Matrix metalloproteinase that cleaves vWF multimers found in
Thrombotic thrombocytopenia purpura
95
antibody in primary membranous glomerulonephritis
anti-phospholipase A2 receptor
96
HIT(Heparin-induced thrombocytopenia antibody
antibody against platelet factor 4
97
Anti-21-hydoxylase
Addison dz congenital adrenal insufficiency
98
Sterp. Pyogenes M protein
Anti-myosin, anti-valve-derived protein molecular mimicry (mitral valve)
99
IgM against RBC..pos combo test
cold agglutination (CMV and mycoplasma, CLL)
100
pos Coombs test, autoimmune hemolytic anemia warm agglutination
IgG against RBCs

Random (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions