Immune System 3

Question 1

What are the key components of the inflammatory response?

Answer 1

Chemical signal from tissue resident cells act to attract more cells to the site of injury or infection
Neutrophils enter blood from bone marrow
Neutrophils cling to capillary wall
Chemical signals from tissue resident cells dilute blood vessels and make capillaries leakier
Neutrophils supqueese through the leaky capillary wall and follow chemical trail to injury site

Question 2

What enzymes apart involved in the killing and digestion of phagocytosis organisms?

Answer 2

Protease
Lipase
Nucleases

Question 3

Describe the classical pathway

Answer 3

Antibody bound to pathogen binds complement

Question 4

Describe the alternative pathway

Answer 4

Pathogen binds complement to surface pathogen component

Question 5

Describe the lectin pathway

Answer 5

Carbohydrate components of microbes bind compliment

Question 6

Descriptive the label outcome

Answer 6

Opsonisation (labels pathogens which bind to Complement receptors on phagocytes)
C3b

Question 7

Describe the destroy outcome

Answer 7

Membrane attack complex formation. Pores in bacterial cells die
C9

Question 8

Describe the recruit pathway

Answer 8

Compliment proteins act as peptide mediators of inflammation and recruit phagocytes
C3a and C5a

Question 9

What is opsonisation

Answer 9

Coating of a microbe with anitibody and or compliment fragment

Question 10

What happens during recruit

Answer 10

Phagocytes are attracted into the site
Most cells degranulated by C3a and C5a
Inflammatory mediators released including proteins that attract phagocytes

Question 11

What happens during destroy?

Answer 11

Microbes coated with C3b are phagocytosed

Assembly of MAC complex causes lysis