Immune System Flashcards
(43 cards)
What type of T cells are CD4
Helper
What type are CD8
Cytotoxic
What are the self antigens
MHC
Where are MHC1 found
All cells
Where are MHC2 found
Dendritic cells
APCells
MHC1 present
Endogenous proteins
MHC2 cells present
Exogenous proteins
Where are MHC 1 loaded
ER
Where are MHC2 loaded
Phagolysosome
Invariant protein prevents binding at ER
When are T cells activated
When TLR binds to MHC
What cell recognizes MHC1
CD8
What cells recognize MHC2
CD4
What and when interacts directly with B cells
Helper T
When have antigens in MHC2
Stimulate proliferation
What does T cell stimulate B cell to do
Colonial expansion
Memory helper T made
What do cytotoxic t cells look for
Antigens in MHC1 Virus Cancer Hiding bacteria Transfusion
What do T cells release
Perforin
Granszyme
What does Perforin do
Causes pore
Lysis
What does granzyme do
Enter through pore
Signal apoptosis
What is the function of regulatory T cells
Release cytokines Suppress T and B cells Protect gut bacteria Protect fetus Prevent autoimminity
What is a congenital immunodeficiency
SCID Deficit in B and T cells Abnormal interleukins Defective adenosine deaminase Substances lethal to T cells build up
What is hodgkins
Lymph node cancer
Immunodeficiency
What are 2 opportunistic infections from aids
Pneumonia
Kaposis sarcoma
What causes aids
Destroyed CD4
From HIV
Examples of autoimmune disease
MS
Type one DM
Rheumatoid arthritis
