Immune System

Question 1

Most potent eosinophil activating cytokine

Answer 1

IL-5

Question 2

Opsonization complement in type 2 hypersensitivity

Answer 2

C3b

Question 3

Inflammation complement in type 2 hypersensitivity

Answer 3

C3a and C5a

Question 4

Common tissues involved in Type III Hypersensitivity

Answer 4

Kidneys
Joints
Small blood vessels

Question 5

CD8 cell action in type IV hypersensitivity is through

Answer 5

Perforins

Granzymes- cleave and activate caspases

Question 6

Accumulation of mononuclear cells, mainly CD4 and macrophages around venules, producing perivascular “cuffing”

Answer 6

Tuberculin reaction

Question 7

Best screening test for SLE

Answer 7

ANA antibody

Question 8

Specific for SLE antibodies

Answer 8

Anti -Smith

Anti- dsDNA

Question 9

Lupus nephritis type where there is swelling and hypercellularity
Affecting <50% of glomeruli

Answer 9

Focal (Class 3)

Question 10

Lupus nephritis class where there is wire loop appearance of capillaries and >50% glomeruli affected

Answer 10

Diffuse (Class 4)

Question 11

Lupus nephritis class where there is >90% sclerosis of glomeuli

Answer 11

Advanced sclerosing (Class 6)

Question 12

Drug induced lupus is associated with anti histone antibodies and these drugs

Answer 12

Hydralazine
INH
Procainamide
D-Penicillamine

Question 13

Dry eyes
Dry mouth
Autoimmune destruction of lacrimal and salivary glands

Answer 13

Sjogren

Question 14

Diagnosis for Sjogren syndrome

Answer 14

Lip biopsy

Question 15

Most important and most common autoantibodies detected in Sjogren

Answer 15

Anti Ro and Anti La

Question 16

Triad of Scleroderma

Answer 16

Chronic inflammation
Widespread damage to small blood vessels
Progressive interstitial and perivascular fibrosis in the skin and multiple organs

Question 17

CREST syndrome of Scleroderma

Answer 17

Calcinosis
Raynaud phenomenon
Esophageal dysmotility
Sclerodactyly
Telangiectasia

Question 18

Autoantibodies in diffuse scleroderma

Answer 18

Anti DNA topoisomerase I (anti-scl 70)

Question 19

Autoantibodies in limited scleroderma

Answer 19

Anti centromere

Question 20

Most common antibody associated with scleroderma renal crisis

Answer 20

Anti-RNA pol III

Question 21

Most common extracutaneous manifestation of scleroderma

Answer 21

Raynaud phenomenon

Question 22

Most common cause of death in scleroderma

Answer 22

Interstitial lung disease and pulmonary arterial hypertension

Question 23

Most commonly seen in both limited and diffuse cutaneous scleroderma

Answer 23

Skin involvement

Raynaud phenomenon

Question 24

Autoantibody in mixed connective tissue disease

Answer 24

Anti-RNP particle containing U1 RNP

Question 25

Presentation of mixed connective tissue disease

Answer 25

Synovitis of the fingers Raynaud phenomenon Mild myositis

Question 26

Usual organs affected in Graft vs Host disease

Answer 26

Skin GIT HBT Immune system

Question 27

``` X linked recessive Btk gene defect No B cell development Symptoms at 5-6 months of life Absent germinal centers and plasma cells Infections of respiratory tract, viral, Giardia lamblia ```

Answer 27

Bruton X agammaglobulinemia

Question 28

Treatment for Bruton agammaglobulinemia

Answer 28

Immunoglobulin replacement

Question 29

X linked disturbance of early T lymphocyte development

Answer 29

Severe combined immunodeficiency