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IMMUNOLOGY AND SEROLOGY :) > IMMUNOGEN VS ANTIGENS > Flashcards

IMMUNOGEN VS ANTIGENS Flashcards

(58 cards)

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1
Q

Macromolecules that is capable triggering an
adaptive immune response by inducing
formation of antibodies or sensitized T cells
of an immunocompetent host

A

Immunogen

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2
Q

Can evoke an immune response

A

Immunogen

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3
Q

Substances that reacts with antibody or
sensitized T cells but may not evoke an
immune response

A

Antigen

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4
Q

Bind sensitized T cells or antibodies
* Not capable of sensitizing naive T cells

A

Antigen

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5
Q

Not capable of sensitizing naive T cells

A

Antigen

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6
Q

ability to induce a humoral and/or cell-mediated immune response

A

Immunogenicity

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7
Q

ability to combine specifically with the final products of the immune response

A

Antigenicity

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8
Q

Enumerate the Factors Influencing the Immune Response

A

Age
Overall health
Dose
Route of inoculation
Genetic Capacity

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9
Q

Route of inoculation:
defined as into a vein

A

Intravenous

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10
Q

Route of inoculation:
defined as into the skin

A

Intradermal

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11
Q

Route of inoculation:
beneath the skin

A

Subcutaneous

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12
Q

Example of intravenous route

A

Spleen

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13
Q

Example of subcutaneous route

A

Local lymph nodes

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14
Q

TRUE OR FALSE:
All immunogens are considered as antigens but not all antigens are considered as immunogens

A

TRUE

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15
Q

TRUE OF FALSE:
All antigens are considered as antigens but not all immunogens are considered as immunogens

A

FALSE

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16
Q

A system of genes that code for cell
surface molecules that play an important
role in antigen recognition

A

MHC (Major Histocompatibility Complex)

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17
Q

It also has something to do with transplantation

A

MHC (Major Histocompatibility Complex)

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18
Q

Molecular weight of immunogens

A

10,000 Da

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19
Q

TRUE OR FALSE for Macromolecular size:
The greater the molecular
weight, the more potent the
molecule to induce an
immune response

A

TRUE

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20
Q

Enumerate the traits of immunogens

A
  1. Macromolecular size
  2. Foreignness
  3. Chemical composition and molecular
    complexity
  4. The ability to be processed and presented
    with MHC molecules
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21
Q

A trait of immunogen Lymphocyte capable of reacting with
self-antigen is normally eliminated

A

Foreignness

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22
Q

TRUE OR FALSE for foreignness:
The more taxonomically
distant the source of
immunogen is from the host,
the more successful it is as a
stimulus

A

TRUE

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23
Q

Defined as the best immunogens

A

Proteins and polysaccharides

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24
Q

Defined as the less immunogenic

Study These Flashcards
A

Carbohydrates

25
TRUE OR FALSE: Poor immunogen cannot be degraded and presented with MHC molecules
TRUE
26
Antigenic determinants
Epitopes
27
Epitopes are molecular shapes or configurations that are recognized by?
B or T cells
28
Example: amino acids following one another on a single chain
Sequential or Linear Epitopes
29
Results from the folding of one chain or multiple chains, bringing certain amino acids from different segments of a linear sequence or sequences into close proximity with each other so they can be recognized together
Conformational Epitopes
30
Recognition of Epitopes by T cells are able to recognize an immunogen it must first degraded into small peptides by a/an?
Antigen-presenting cell (APC)
31
Small organic molecules that are antigenic but not immunogenic
Hapten
32
Capable of reaction with antibody however precipitation or agglutination will not occur
Hapten
33
Defined as the Coupling to a carrier
hapten-carrier conjugate
34
An example of hapten is
Poison Ivy
35
He discovered that antibodies not only recognize chemical features such as polarity, hydrophobicity, and ionic charge, but the overall threedimensional configuration is also important
Karl Landsteiner
36
Substance administered with an immunogen that increases the immune response in order to provide immunity to a particular disease
Adjuvants
37
used to complex with the immunogen to increase its size and to prevent a rapid escape from the tissues.
aluminum salts
38
Antigens that belong to the host
Autoantigens
39
Do not evoke an immune response under normal circumstances
Autoantigens
40
from other members of the host’s species
Alloantigens
41
Capable of eliciting an immune response
Alloantigens
42
From other species such as other animals, plants or microorganisms
Heteroantigens
43
Heteroantigens that exist in unrelated plants or animals
Heterophile antigens
44
Either identical or closely related in structure so that antibody to one will cross-react with antigen of the other
Heterophile antigens
45
Glycoproteins that recognize and bind to a particular antigen with very high specificity
Antibody
46
Made in response to exposure to the antigen
Antibody
47
Antibodies: Each antibody has at least two identical sites that bind antigen (epitope is for ____ + paratope is for ___)
Epitope - Ag Paratope - Ab
48
Antibodies Belong to a group of serum proteins called
immunoglobulins (Igs)
49
What is the pH of Electrophoresis? and immunoglobulins appear primarily in what band?
pH 8.6 Gamma bands
50
What theory states that a certain cells had specific surface receptors for antigen
Ehrlich’s Side-Chain Theory
51
What theory states that an Occurred once antigen was introduced, it would select the cell with proper receptor, combination would take place and receptors would break off and enter circulation as antibody molecules
Ehrlich’s Side-Chain Theory
52
What theory states that a New receptors would form in place of those broken off and enter the circulation as antibody molecules
Ehrlich’s Side-Chain Theory
53
Template Theory was discovered by?
Felix Haurowitz
54
What theory states that an Antibody producing cells are capable of synthesizing a generalized type of antibody, and when contact with an antigen occurs, the antigen serves as a mold or template and alters protein synthesis so that antibody with a specific fits is made
Template Theory
55
What theory states that it is now a specific antibody enters the circulation, while the antigen remains behind to direct further synthesis
Template Theory
56
Most accepted theories of antibody diversity
Clonal Selection
57
Clonal Selection was discovered by
Niels Jerne and Macfarlane Burnet
58
What theory states that The key premise is that individual lymphocytes are genetically programmed to produce one type of immunoglobulin and that a specific antigen finds or selects those particular cells capable of responding to it, causing to proliferate
Clonal Selection

IMMUNOLOGY AND SEROLOGY :) (8 decks)

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