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IMMUNOLOGY AND SEROLOGY :) > OVERVIEW OF IMMUNE SYSTEM > Flashcards

OVERVIEW OF IMMUNE SYSTEM Flashcards

1
Q

Refers primarily to anatomical,
cellular, and humoral defenses that
functions in the early stages of host
defense

A

Innate Immunity/Non-specific Immunity
(1st and 2nd Line of Defense)

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2
Q

Second line of defense:
Enumerate the cellular factors

A
  1. Phagocytes
  2. Basophils & Mast Cells
  3. NK cells
  4. APCs
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3
Q

Second line of defense:
Enumerate the non-cellular factors

A
  1. Complement System
  2. Cytokines
  3. INF
  4. Inflammatory reactions
  5. Acute reactants
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4
Q

Low ph of stomach and vagina

A

Acid

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5
Q

Example of flushing actions

A

blinking of eyelids
peristalsis
urination

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6
Q

Enumerate the Secretion of Factors

A
  1. Interleukin 1
  2. Interleukin 6
  3. Complement
  4. Hydrolytic enzymes
  5. Tumor necrosis
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7
Q

promotes inflammatory response

A

Interleukin 1

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8
Q

promotes innate immunity

A

Interleukin 6

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9
Q

promotes elimination of pathogens
through cell lysis

A

Complement

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10
Q

promotes inflammatory
response

A

Hydrolytic enzymes

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11
Q

kills tumor cells

A

Tumor necrosis

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12
Q

Increase rapidly due to infection, injury, or
trauma to the tissues

A

Acute Phase Reactants

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13
Q

Acute phase reactants are Produced primarily by

A

hepatocytes

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14
Q

(liver parenchymal cells) within 12 to 24 hours
in response to an increase in certain
intercellular signaling polypeptides called

A

cytokinesis

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15
Q

Other name for IFN-alpha

A

Leukocyte IFN

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16
Q

Primary producers of IFN alpha

A

Null lymphocytes

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17
Q

Other name for IFN-beta

A

Epithelial
Fibroblast IFN

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18
Q

Primary producers of IFN beta

A

Fibroblasts, epithelial cells, MACs

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19
Q

Function of IFN beta

A

Anti-viral

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20
Q

Other name for IFN-gamma

A

Immune IFN

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21
Q

Primary producers of IFN-gamma

A

T helper 1 cells, T cytotoxic cells

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22
Q

Cells that engulf and digest foreign materials

A

Phagocytes

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23
Q

Examples of phagocytes are

A

Neutrophils (PMNs)
Monocytes
Macrophages
Dendritic cells
Fixed Phagocytes

24
Q

Locations of Macrophages (MACs):
Histocytes

A

Connective tissue

25
Q

Locations of Macrophages (MACs):
Alveolar MACs

A

lungs

26
Q

Locations of Macrophages (MACs):
Kupffer cells

A

liver

27
Q

Locations of Macrophages (MACs):
Littoral cell

A

Spleen

28
Q

Locations of Macrophages (MACs):
Mesangial cells

A

kidney

29
Q

Locations of Macrophages (MACs):
Microglia

A

brain

30
Q

Locations of Macrophages (MACs):
Osteoclasts

A

Bone

31
Q

Locations of Macrophages (MACs):
Synovial A cells

A

Synovial fluid

32
Q

Locations of Macrophages (MACs):
Hof-Bauer cells

A

Placenta

33
Q

Locations of Macrophages (MACs):
Langerhans cells

A

Epidermis

34
Q

Indirect interaction:
It is the enhancement of
phagocytosis (C3b, IgG1 and
IgG3)

A

Opsonization

35
Q

Direct interaction:
Pattern Recognition Receptors
(PRRs): phagocytes use their
PRRs to recognize and adhere to
______

A

Pathogen Associater Molecular
Patterns (PAMPS)

36
Q

Transcribe PRPs

A

Pattern Recognition Receptors
(PRRs)

37
Q

Ingestion (Engulfment):
Vacuole + Pathogen = ________

A

PHAGOSOME

38
Q

Example of oxygen dependent mechanisms which are toxic reactive oxygen intermediates

A

Superoxide anion
Hydrogen peroxide
Hydroxyl radical

39
Q

Example of oxygen dependent mechanisms which are myeloperoxidase

A

Hypochlorite and highly toxic substances

40
Q

Oxygen Independent Mechanisms:
It has an antibiotic like peptides made by phagocytes

A

Defensins

41
Q

Example of digestive enzymes

A

Lysozymes and lactoferrin

42
Q

NK cells that Exist in the body at birth

A

Nonspecific Immunity

43
Q

NK cells that are not produced by immunologic insult

A

Nonspecific Immunity

43
Q

Transcribe ADCC

A

Antibody Dependent Cellular
Cytotoxicity

44
Q

NK cells Form ______ in Sheep RBC

A

Rosette

45
Q

NK Cells:
Responsible for the NK cell exposed to IL-2 and IFN gamma

A

Lymphokine Activated Cell (LAK)

46
Q

Transcribe LAK

A

Lymphokine Activated Cell (LAK)

47
Q

Method of Killing
Formation of Pores
causing lysis

A

Perforins

48
Q

Method of Killing
Programmed Cell Death

A

Apoptosis

49
Q

Overall response of the body after tissue damage or invasion infectious agent

A

Inflammation

50
Q

Inflammation:
Rubor

A

redness

51
Q

Inflammation:
Calor

A

heat

52
Q

Inflammation:
Tumor

A

swelling

53
Q

Inflammation:
Dolor

A

pain

54
Q

Inflammation:
Function Laesa

A

loss of function

IMMUNOLOGY AND SEROLOGY :) (8 decks)

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