Flashcards in Immunologic Therapies Deck (22):
Targets B cells by crosslinking DNA inhibiting DNA replication. Used in treating Goodpasture's.
Inhibits TLRs and decreases acidity of lysosomes (retinal toxicity)
Anti-CD20 Ab. Located on B cells (does not delete plasma cells)--> leads to no Ab production
Drug that fuses the extracellular domain of CTLA-4 & Fc region of IgG1. Binds to B7-1/2 and leads to T cell unresponsiveness. Used to manage RA.
1st line pain reliever, possible hepatotoxicity, Minimal side effects.
Blocks DHFR, increases adenosine and decreases inflammation
COX-1 inhibitors. GI, Renal, and inhibited platelet aggregation risk factors.
Ketorolac and Asprin
COX-2 inhibitors; Cardiovascular risks.
Celecoxib and Diclofenac
Drug that blocks IL-2 and is used for acute organ rejection.
Inhibitor of nucleotide synthesis, Inhibits B and T proliferation, Ab synthesis, and NK cell activity. Given to Goodpasture's syndrome patients
a. Infliximab (Remicade)
b. Adalimumab (humira)
c. Etanercept (Enbrel)
d. Certolizumab (Cimzia)
e. Golimumab (Simponi)
Ab against Fc portion of IgE. Aids in type I hypersensitivity reaction.
Inhibits formation of NFAT by blocking de-phosphorylation of P-NFAT by activated Calcineurin. Used in Stevens Johnson Syndrome
Eliminates fetal RBCs from mom's circulation
Turns off maternal B cells by cross-linking BCR & FcyRII
Pyrimidine synthesis blocker and teratogen
Purine synthesis inhibitor
Increases liver production of C1 inhibitor, Treatment of HAE