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Flashcards in Immunology Deck (13):
1

What are the receptor and ligand for APC and T cells?

CD28 on T cells, B7 on APC

2

What are the receptor and ligand for B cells and T cells?

CD40L on T cells, CD40 receptor on B cells

3

What is IL-2's receptor?

CD25

4

What is the most important inflammatory factor in the body?

TNF

5

What is the function of TNF? alpha, beta, gamma?

antiviral activity, tumoricidal effect
alpha and beta made by macrophages
gamma made by T cells and stimulates macrophages (activates them)

6

What is IL2 made by? What does it stimulate?

made by T cells, stimulates B cells and macrophages

7

What is IL-4's function?

Bcell growth factor (stimulation of B cell by T cell)
Tcell growth factor and regulator of T cell function

8

What type of Tcell response is IL-10 produced by?

TH2 response, may suppress TH1 cytokines

9

What interleukin stimulates TH1 response?

IL-12

10

What is the primary mediator of septic shock in humans?

TNFalpha, responsible for vascular damage and fever

11

Describe TH1 response

activate CMI by producing IL-2, IFN gamma, TNFbeta
promoted by IL-12

12

Describe TH2 response

active B cells by producing IL-4, IL-5, IL-6

13

What is IL-5's function?

B cell growth factor and differentiation factor