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NDBE Part 1: Microbio & Pathology > Immunology > Flashcards

Flashcards in Immunology Deck (43)
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1

Primary Ab of humoral immune response:

IgM

2

Secondary Ab of humoral immune response:

IgG

3

Primary Ab and cells in type I hypersensitivity rxns:

IgE
Mast cells (basophils)
Granules (histamine)

4

What cytokines work on fever?

IL-1 and IL-6

5

What cytokine stimulates hematopoietic ells?

IL-3

6

What cytokine stimulates IgA and eosinophils?

IL-5

7

What cytokine stimulates IgE?

IL-4

8

What cytokine aids in PMN chemotaxis?

IL-8

9

What cytokine aids adhesion molecules?

TNF-alpha

10

What cytokine stimulates collagen formation during wound healing?

TGF-beta

11

What is the principle mediator of anaphylaxis?

histamine

12

What is the principle mediator of asthma?

leukotriene

13

What is the principle mediator of inflammation?

prostaglandin

14

What is the principle mediator of pain?

bradykinin

15

Thromboxane inc/dec platelet aggregation?

inc (vasoconstrictor)

16

Prostacyclin inc/dec platelet aggregation?

dec (vasodilator)

17

What activate compliment?

2 IgG
1 IgM (pentameric)

18

Where are monocytes derived from?

histiocytes (bone marrow)

19

What cytokines do macrophages secrete?

IL-1, 6, 8, TNF, INF

20

What 2 gourds of infectious invaders give you caseating granulomas?

TB and dimorphic fungi

21

What happens during opsonization?

tag w/ FC portion of IgG
receptors for C3b
coating of bacteria

22

What activates NK cells?

IL-12, INF-gamma

23

CD4 relates to what T-cell and MHC?

T-helper cells
Class II MHC

24

CD8 relates to what T-cell and MHC?

cytotoxic T-cells
Class I MHC

25

Type I CD-4s secrete what?

IL-2, INF-gamma

26

Type II CD-4s secrete what?

IL-4, IL-5

27

What makes up the recognition unit?

Ab (FC portion) + Ag
C1q, r, s

28

what complement component is responsible for immune adherence phenomenon?

C3b

29

what are 2 anaphylactic toxins in complement cascade?

C3a
C5a

30

What immune unit acts on C5?

C3b + C4 + C2