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MRCOG part 1 > Immunology > Flashcards

Immunology Flashcards

1
Q

what are antibodies molecularly

A

glycoproteins

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2
Q

Hypersensitivity

A

1 - IgE - immediate
2 - antibody dependent, IgM, IgG
eg: haemolytic disease of the newborn, good pastures, pernicious anaemia
3 - deposition of immune complexes - Arthus reaction
4 - Delayed. T cell immunity e.g.: Mantoux

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3
Q

Complement system
What are they
Where are they made

A

Glycoproteins - around 20

made in the liver

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4
Q

How is the complement system activated

A
  1. C1 binding to an antibody which has been activated to an antigen
  2. C3 activation - independent of antibodies
  3. Mannose-lectin activation pathway

C3 is cleaved to form C3a

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5
Q

NK cells

A 
innate immunity
lymphocytes
Recognise failure to express MHC 1
Cytotoxic
release performs and granzyme to cause apoptosis
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6
Q

Examples of live attenuated vaccines

A

MMR
BCG
Polio (sabin)

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7
Q

Examples of inactivated vaccines

A

hep A
pertussis
influenza
polio (salk)

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8
Q

toxoid vaccines

A

tetanus and diptheria

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9
Q

Example of subunit vaccine

A

Hep B

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MRCOG part 1 (12 decks)

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