Immunology

Question 1

ANA pattern: Homogeneous

Answer 1

SLE - High titers

Sjogren, MCTD, RA - Low titers

Question 2

ANA pattern: Rim pattern

Answer 2

PBC, Chronic liver disease, drug induced SLD

Question 3

ANA pattern: Speckled

Answer 3

SLE, MCTD, Sjorens, scleroderma

Question 4

ANA pattern: Nucleolar

Answer 4

scleroderma

Question 5

ANA pattern: Centromere

Answer 5

Scleroderma (with crest syndrome) , raynaud

Question 6

High anti-RNP (>1:10,000)

Answer 6

MCTD

Question 7

Anti-SS-A/Ro &; SS-B/La

Answer 7

Sjogren

Question 8

Anti-Scl-70 (anti-topoisomerase 1)

Answer 8

Progressive systemic sclerosis

Question 9

Anticentromere

Answer 9

CREST

Question 10

Positive ANA and anti-histone

Answer 10

Drug Induced Lupus, directed against H2A-H2B

Question 11

What organism is required for the anti-dsDNA detection?

Answer 11

Crithidia luciliae

dsDNA in the kinetoplast of the organism

Question 12

Anti-mitochondrial ab M2

Answer 12

PBC

Question 13

Anti-LKM

Answer 13

Autoimmune Hepatitis 2

Children 2-14 and adults
Severe with freq relapse

Question 14

C-ANCA

Answer 14

Wegener

Question 15

P-ANCA

Answer 15

PSC
UC
microscopic polyangiitis
polyarteritis nodosum
Churg- Strauss

Question 16

Anti-Jo

Answer 16

Polymyositis with pulmonary fibrosis

Question 17

Anti-endomysial

Answer 17

Celiac sprue and dermatitis herpetiformis

Question 18

Anti- gliadin

Answer 18

celiac

Question 19

anti-tissue tranglutaminase

Answer 19

celiac

Question 20

Anti-GBM, M2

Answer 20

good pasture

Question 21

Anti-CCP

Answer 21

RA

Question 22

HLA-A3

Answer 22

Hereditary hemochromatosis

Question 23

HLA-C4

Answer 23

21-hydroxylase deficiency

Question 24

HLA-B27

Answer 24

Akylosing sponylitis

Question 25

HLA-B51

Answer 25

Behcet

Question 26

HLA-DQ2, DQ8

Answer 26

Celiac

Question 27

HLA-DR3 and 4

Answer 27

DM

Question 28

HLA-DRB1

Answer 28

MS

Question 29

HLA-DR4

Answer 29

RA

Question 30

Drugs associated with drug induced lupus

Answer 30

Procainamide, hydralazine, quinidine, isoniazid, interferon-a

Question 31

CREST stands for?

Answer 31

``` Calcinosis Raynaud Esophageal sclerosis Sclerodactyly Telangiectasia ```

Question 32

Anti-SMA and anti-ANA

Answer 32

Autoimmune Hepatitis 1 Bimodal 10-20 and 45-70

Question 33

Name deficiencies: Recurrent infection with gram + encapsulated bacteria

Answer 33

C2 , C3

Question 34

Name deficiencies: Recurrent infection with N meningitis

Answer 34

C5- C9

Question 35

Name deficiencies: Recurrent infection with catalase + bacteria ( staph, enterobacter, aspergillus)

Answer 35

NADPH oxidase deficiency , Chronic granulomatous disease

Question 36

Whats the test for Chronic granulomatous disease

Answer 36

Nitroblue tetrazolium

Question 37

Name deficiencies: 6 month old with recurrent bacterial infection, especially those encapsulated

Answer 37

Bruton agammaglobulinemia

Question 38

Name deficiencies: 20 yr old with recurrent respiratory tract infection and giardia

Answer 38

Common variable immunodeficiency

Question 39

Name deficiencies: Hereditary angioedema

Answer 39

C1q esterase inhibitor

Question 40

Name deficiencies: autoimmune disease

Answer 40

Classical pathway (C1q, C2, C4)

Question 41

Anti-mitochondrial: M1

Answer 41

Syphilis

Question 42

Anti-mitochondrial: M2

Answer 42

PBC

Question 43

Anti-mitochondrial: M5

Answer 43

collagen vascular disease

Question 44

Anti-mitochondrial: M7

Answer 44

cardiomyopathy

Question 45

Anti- Jo1, SRP, PM/Scl

Answer 45

Dermatomyositis and Polymyositis

Question 46

Which ab in polymyositis has worse prognosis?

Answer 46

Anti-SRP- associated with cardiac manifestation and HLA DR5

Question 47

Anti- AChR

Answer 47

Myasthenia Gravis

Question 48

Anti SLA (soluble liver ag) and Anti- LP (liver pancreas)

Answer 48

Type 3 30-50