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Malignant Heme Flashcards

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1
Q

CLL/PLL is defined as?

A

11-55% PLL

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2
Q

Smudge cells artifacts caused by ?

A

EDTA(purple) – also satellitosis is seen in EDTA

You dont see either with Heparin (green)

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3
Q

In CLL, the most common cytogenetic abnormality is ___ but by FISH, the most common anomaly is _____

A

Trisomy 12

Fish: del 13q14

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4
Q

Whats the RAI and the Binet?

A 
Rai
0 Lymphocytosis
I. Lymphadenopathy
II. hepatosplenomegaly
III. anemia (=<11)
IV. Thrombocytopenia (<100,000)

Binet
A < 3 lymphoid areas
B >3 lymphoid areas
C Anemia and thrombocytopenia

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5
Q

CD19, CD20(dim), CD22, CD5, CD43, CD23, sIg (dim), CD79a, CD11c(dim), bcl-2

A

CLL

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6
Q

CD19, CD20(bright), CD22, FMC-7, CD5, CD43, sIg(Bright) bcl-1, CD99

A

Mantle

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7
Q

Adverse prognosis for mantle?

A

> 10 mitosis/hpf

Ki-67 >40%

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8
Q

Diffuse growth in FL is defined as?

A

follicular architecture with a lack of CD21 and or CD23

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9
Q

Prognosis of FL is adversely affected by?

A

Higher age, stage, serum LD, BM involvement, B symptoms, anemia, low performance status

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10
Q

CD19, CD20, CD22, sIg, CD11c(Bright), CD25(bright), CD103, DBA.44. annexin A1, cyclin D1(dim,nuclear)

A

Hairy cell

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11
Q

LPL with an IgM monoclonal gammopathy and marrow involvement is?

A

Waldenstrom macroglobulinemia

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12
Q

Waldenstrom is associated with?

A

HCV and cryoglobulinemia

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13
Q

t(9:14) Pax5 gene and C region of IgH is seen in?

A

LPL

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14
Q

Which bacteria is associated with a form of MALT lymphoma called the immunoproliferative small intestine disease (mediterranearn lymphoma)

A

Campy jejuni

This heavy chain disease is associated with the alpha type.

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15
Q

Franklin H chain disease (y heavy chain disease) seen in?

A

LPL

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16
Q

u heavy chain disease is seen in?

A

CLL

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17
Q

GCB-like DLBCL is associated with?

A

better prognosis

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18
Q

BM infiltration by TCRBCL is

A

paratrabecular

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19
Q

Which large B lymphoma is associated with
MAL gene alteration
Females
no rearrangement of BCL2 or BCL6
Large b cells entrapped within bands of scleorsis?

A

Primary mediastinal (thymic) large b cell lymphoma

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20
Q

HIV/HHV8 combo seen in?

A

Kaposi
PEL
Castleman

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21
Q

Which Large B cell Lymphoma

resembles vasculitis
Associated with EBV and immunodeficiency
Uncommon granulomas
large number of reactive T cells, plasma, histiocytes

A

Lymphomatoid granulomatosis

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22
Q

CD19, CD20, CD22, CD10, bcl-6, sIg, C-myc

A

Burkitt

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23
Q

In B-ALL, what are the favorable findings?

A

Low initial white count (<50,000)
2-10 years
Female
Hyperdiploidy

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24
Q

IN B-ALL with recurrent abnormalities, which are good prognosis?

A

t(12;21) TEL-AML1
Hyperdiploid >50

Both seen in 25% of children

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25
IN B-ALL with recurrent abnormalities, which are associated with badprognosis?
t(9;22) 190k Most common and worst t(v;11) MLL CD10- Hypodiploid t(1;19) E2A-PBX1
26
IN B-ALL with recurrent abnormalities, which is associated with eos?
t(5;14) IL3-IGH - NO CHANGE IN PROGNOSIS in AML its inv(16)
27
With MM by fish, what has the shortest survival median of 24 months?
t(4;14), t(14;16) or 17p13 deletion
28
With MM by fish, what has the longest survival median of >50 months?
Nothing or just t(11;14)
29
Smoldering myeloma vs MGUS
Smoldering M protein >3g/dl or clonal plasma cells in marrow is >10% MGUS is less
30
Which T cell lymphoma is EBV associated, older adults coombs+ autoimmune hemolytic anemia, cold agglutinins, anti-smooth muscle antibody, rheumatoid factor, and polyclonal hypergammaglobulinemia?
AITCL | Angioimmunoblastic
31
Which T cell lymphoma is associated with HTLV-1 CD25 +
ATCL | Adult T cell leukemia/lymphoma
32
Which T cell lymphoma is neutropenia, splenomegaly, polyclonal hypergammaglobulienmia Older males' Rheumatoid arthritis
T cytotoxic LGL leukemia
33
Which T cell lymphoma is young males B symptoms isochrome 7q
Hepatosplenic TCL gamma delta type Alpha beta more seen in females
34
Which Hodgkin has the highest associated with EBV?
Mixed Cellularity- CHL 75% Also assoc. with HIV LR and LD is 50% NS is 25%
35
Sideroblasts have at least ___ siderosomes that surround ___ of the nucleus
Sideroblasts have at least 5 siderosomes that surround 1/3 of the nucleus
36
SF3B1 mutation in MDS is called?
MDS with ringed sideroblasts
37
Dyspoiesis must be present in ___ or more of a cell line to be called dysplastic
Dyspoiesis must be present in 10% or more of a cell line to be called dysplastic
38
Favorable prognosis for MDS?
Normal | isolated loss of Y,5q-, 20q-
39
Unfavorable prognosis for MDS?
3 more more anomalies | anomalies of chromosome 7
40
JAK2 is most commonly seen in?
PV
41
Name that AML translocation/gene name and Prognosis? Thrombocytosis giant agranular platelets Adults
AML with inv 3 or t(3;3) RPN1/EVI1 Poor prognosis
42
Name that AML translocation/gene name and Prognosis? Basophilia Children/adults
t(6;9) DEK/NUP214 | poor prognosis
43
Name that AML translocation/gene name and Prognosis? Megakaryocytic CD34 and HLA-DR negative INfants
t(1;22) RBM15/MLK1 | intermediate prognosis
44
Name that AML translocation/gene name and Prognosis? ``` Abundant gray blue cytoplasm Auer rods large granules CD19+ YOung adults ```
t(8;21) RUNX1/RUNX1T1 | Favorable
45
Name that AML translocation/gene name and Prognosis? abnormal eos- stain with naphthyl acetate esterase lysozyme and CD2 pos young adults
inv (16) MYH11/CBFb | favorable
46
Name that AML translocation/gene name and Prognosis? Promyelocytes CD34 and HLADR neg Middle age Females
t(15;17) PML/RARa | favorable
47
In AML with myelodysplasia related changes, how much dysplasia is need?
>50% in 2 cell lines
48
Which AML is associated with mediastinal germ cell tumors and i12p?
Acute megakaryoblastic leukemia M7
49
CD2 positive, surface CD3 negative, CD4 negative, CD5 negative, CD8 positive/negative, CD34 negative, CD56 positive, TdT negative, and Epstein Barr virus (EBV) positive.
Aggressive natural killer (NK)-cell leukemia
50
CD2 positive, CD3 positive, CD4 negative, CD5 negative, CD8 negative/positive, CD19 negative, CD34 negative, CD56 positive/negative, TdT negative, and EBV negative.
Hepatosplenic T-cell lymphoma
51
CD2 negative, CD3 negative, CD4 negative, CD5 negative, CD8 negative, CD19 negative, CD34 negative, CD56 positive/negative, TdT negative, and EBV negative. In addition, the cells are CD138 positive, CD38 positive (bright), CD79a positive, and CD20 negative/positive.
Plasma cell leukemia
52
CD2 positive, surface CD3 negative, CD4 negative, CD5 negative, CD8 positive/negative, CD19 negative, CD34 negative, CD56 positive, TdT negative, and EBV positive.
Extranodal NK/T-cell lymphoma
53
CD3 positive, CD5 positive, CD7 negative, CD4 positive, CD8 negative, and CD25 positive
adult T-cell leukemia/lymphoma
54
hemophagocytic lymphohistiocytosis (HLH) is associated with?
subcutaneous panniculitislike T-cell lymphoma | Hepatosplenic T cell lymphoma
55
``` 5 of the following is diagnostic of? Fever Splenomegaly Bicytopenia Hypertriglyceridemia or Hypofibrinogenemia Hemophagocytosis Hyperferritinemia High sCD35 ```
HLH
56
CD4, CD56, CD123, TCL1
Blastic plasmacytoid dendritic cell neoplasm
57
MYD88 mutations are seen in?
LPL
58
Hairy cell is associated with what mutation?
BRAF V600 E
59
CXCL-13 is expressed by?
AITCL
60
What clinical findings has adverse prognosis in MM?
High B2 microglobulin, high plasma cell labeling index, high stage

Pathology (16 decks)

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