Immunology

Question 1

CD positivity of macrophages

Answer 1

CD14

Question 2

Part of the lymph node that is rich in T cells

Answer 2

Paracortex

Question 3

Asplenia is associated to a decrease in which immunoglobulin

Answer 3

IgM

Question 4

Type of peptides that are bound to MHC class 1

Answer 4

Endogenous

Question 5

Type of peptides that are bound to MHC class 2

Answer 5

Exogenous

Question 6

CD positivity of natural killer cells

Answer 6

CD16 + CD56

Question 7

Cytokines produced by TH2 cells that inhibit TH1 development

Answer 7

IL4 and IL10

Question 8

Cytokine produced by TH1 cells that inhibit TH2 development

Answer 8

IFN-gamma

Question 9

Main characteristic of a thymus-independent antigen

Answer 9

Lacks a peptide component (eg. LPS)

Question 10

Lipopolysaccharide binds to which CD

Answer 10

CD14 of macrophages

Question 11

Hyperacute graft rejection is an example of which type of hypersensitivity

Answer 11

Type 2

Question 12

Rheumatoid arthritis is an example of which type of hypersensitivity

Answer 12

• Type 3

* Joint damage is mediated by type 4

Question 13

Which interleukin is responsible for stopping type 4 hypersensitivity reactions

Answer 13

Interleukin 10

Question 14

First signal for plasma cell activation

Answer 14

CD40L binding on the TH to the CD40 on the B cell

Question 15

Where are macrophages and reticular cells located in a lymph node

Answer 15

Medullary sinuses

Question 16

Part of the lymph node with high endothelial venules

Answer 16

Paracortex

Question 17

Ribs that overlie the spleen

Answer 17

9th - 11th

Question 18

Where are T cells located in the spleen

Answer 18

Periarteriolar lymphatic sheaths (PALS) within the white pulp

Question 19

Where are macrophages located in the spleen

Answer 19

Marginal zone

Question 20

CD that recognizes LPS

Answer 20

CD14 (co-receptor for TLR4)

Question 21

B cell stage where the cytoplasmic and B receptor appear

Answer 21

Pre-B

Question 22

B cell stage with membrane bound IgM

Answer 22

Premature B cell

Question 23

Process that takes place in positive selection of T cells

Answer 23

TCRs capable of binding self-MHC on cortical epithelial cells survive, occurs in the thymic cortex

Question 24

Process that takes place in negative selection of T cells

Answer 24

TCRs with high affinity for self antigens undergo apoptosis, occurs in thymic medulla

Question 25

Deficiency of autoimmune regulator (AIRE) leads to the development of which pathology

Answer 25

Autoimmune polyendocrine syndrome-1

Question 26

Cells that are positive to CD3, CD4, CD25, and FOXP3

Answer 26

Regulatory T cells

Question 27

Deficiency of FOXP3 leads to the development of which pathology

Answer 27

IPEX (Immune dysregulation, polyendocrinopathy, enteropathy, X-linked) syndrome

Question 28

Enzyme that adds random nucleotides to DNA during recombination of VJ or V(D)J genes

Answer 28

Terminal deoxynucleotidyl transferase (TdT)

Question 29

Part of the Fc region that binds to complement

Answer 29

Ch2

Question 30

Triad of reactive arthritis

Answer 30

• Urethritis
• Conjunctivitis
• Mono- or oligo- arthritis

Question 31

Actions of interferon alpha in response to dsRNA

Answer 31

• Inhibits viral replication by inhibiting cellular protein synthesis
• Activates endoribonuclease to destroy viral RNA
• Induces MHC class 1 protein expression