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Heme and lymph Kaplan > Pharmacology > Flashcards

Pharmacology Flashcards

1
Q

DOC in organ or tissue transplant

A

Cyclosporine

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2
Q

Molecular target of sirolimus

A

mTOR

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3
Q

Monoclonal antibodies used to block IL-2 receptors (CD25) in kidney transplants

A
  • Daclizumab

* Basiliximab

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4
Q

Monoclonal antibody that binds to T3 (CD3) on thymocytes

A

Muromonab

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5
Q

Glycoprotein 2b/3a inhibitors

A
  • Abciximab
  • Eptifibatide
  • Tirofiban
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6
Q

Drugs that prevent IL-2 transcription

A
  • Cyclosporine

* Tacrolimus

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7
Q

Drug that prevents response to IL-2

A

Sirolimus

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8
Q

Drug that is associated with invasive CMV infection

A

Mycophenolate mofetil

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9
Q

Antibody against complement C5 protein used in paroxysmal nocturnal hemoglobinuria

A

Eculizumab

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10
Q

Antibody against alpha 4 integrin used in multiple sclerosis

A

Natalizumab

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11
Q

DOC for lead poisoning in kids and adults

A
  • Adults: dimercaprol and EDTA

* Kids: succimer

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12
Q

Mechanism of action of ruxolitinib

A

JAK1/2 inhibitor

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13
Q

Only oral direct thrombin inhibitor

A

Dabigatran

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14
Q

Drug used for reversal of dabigatran

A

Idarucizumab

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15
Q

Thrombolytic that is clot-specific

A

Alteplase

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16
Q

ADP receptor inhibitor that is reversible

A

Ticagrelor

17
Q

EGFR tyrosine kinase inhibitor

A

Erlotinib

18
Q

DOC for hairy cell leukemia

A

Cladribine

19
Q

Calcineurin inhibitors

A
  • Cyclosporine

* Tacrolimus

20
Q

Clinical use of muromonab

A

Used to treat acute rejection

21
Q

Difference between 6-mercaptopurine and 6-thioguanine

A

6-thioguanine can be used in patients taking allopurinol

22
Q

Mechanism of action of cytarabine

A

Direct inhibition of DNA synthase, pyrimidine antimetabolite

23
Q

DOC in patients with heparin-induced thrombocytopenia

A

Bivalirudin

24
Q

Psoriaris can be exacerbated by intake of which antimicrobial

A

Chloroquine

25
Q

Boronic acid-containing dipeptide with high affinity for the proteasome catalytic site, inhibiting it

A

Bortezomib

Heme and lymph Kaplan (3 decks)

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