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Flashcards in Immunology Exam 3 Deck (52):
1

Mechanism/s for cell damage in type II hypersensitivity

A. Classical complement cascade
B. Natural Killer Cells
C. Opsonization
D. ALL OF THE ABOVE

2

Incompatible blood transfusion could induce a hemolytic reaction that results in intravascular lysis of the RBC's and release of _______ from lysed cells.

HEMOGLOBULIN

3

Production of _____ anitibodies may be due to...

A. Emergence of forbidden clone of B cells
B. Production of antibody against sequestered tissue
C. Indirection -induced change in the cell receptors
D. ALL OF THE ABOVE

4

The lack of immune response for self-antigens in the tissue is caused by:

A. Deletion of self reactive cells
B, Inactivating the cell (anergy)
D. A & B

5

This tolerance is unresponsive to self-antigens (all the endogenous antigens).

Natural Tolerance

6

Function of T suppressors cells is important in suppression.

True

7

Antibodies against antibodies called _________.

Anti-idiotype-antibody

8

In Graves' disease, antibodies blood, the TSH (thyroid stimulating hormone) receptors on the thyroid gland.

True

9

Which of the following autoimmune disease is associated with butterfly rash on the face?

Systemic lupus (SLE, Red wolf)

10

Which of the following factors is/are involved in insulin dependent diabetes mellitus autoimmune disease?

A. Infection
B. HLA gene
C. A & B

11

Which one of the following biochemical/s is/are going to be reduced in Hashimoto's Thyroiditis?

Thyroxin

12

Which of the following is called rheumatoid factor?

IgM-antibody against F-c portion of a patient's own IgG

13

Auto-antibodies in double-strained DNA are typical findings in which of the following disorders?

Do not have an answer here, choices:
A. Rheumatoid arthritis
B. Systemic lupus erythematosus
C. Diabetes mellitus
D. Ankylosing spondylitis

14

Multiple sclerosis is associated with which of the following types of hypersensitivity reactions?

III & IV

15

The antibodies in warm agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins?

IgG

16

Allografts of lymphoid tissue are particularly immunogenic because of the high content of

MHC class II expressing cells

17

An example of a type III immune complex disease is

Rheumatoid Arthritis (RA) and Scleroderma (SLE)

18

The localized reactions to injected antigens in the same body site such as booster shoot are called ________

Arthus reaction

19

A positive tuberculin skin test is an example of __________

A delayed type allergy

20

Contact dermatitis is caused by ________

Chemical absorbed by the skin

21

A graft transplanted between individual who are members of different species

Xenograft

22

Factors that affecting the immune system and decrease the immune functions are as follow:

A. Chronic disease
C. Emotional stress
D. A & C

23

Patient with severe immunodeficiency disease in both T-cells and B-cells compartment accept an allogenic bone marrow graft.

TRUE

24

Natural antibodies have the following characteristics:

A. Low affinity
B. Low specificity
C. Harmless
D. have some rule for clearing infection
E. ALL OF THE ABOVE

25

In natural tolerance 95% of apoptosis (PCD) of T-cells found in:

Thymus

26

Central Tolerance is within ________

Thymus

27

Matching:
1. Post-Streptococal (Glomerulonephritis); B
2. Arthus Reaction; C
3. Serum Sickness; A
4. Contact hypersensitivity; D

A. Type III hypersensitive (systemic)
B. Immune complex disease
C. Type III hypersensitivity (local)
D. Type IV

28

T suppressor cells prevent ______ to make antibodies, and also prevent _______ from maturing into T-cytotoxic cells.

B-cells, T cells

29

Preexisting infections can have positive or negative effects on immune response.

TRUE

30

This is an induce tolerance in which an animal will fail to respond to non-self antigens (all exogenous antigens) from outside the body that would normally be immunologic.

Acquired Tolerance

31

Which of the following factors are involved in autoimmune disease

A. Infection
B. Hormonal
C. Genetic
D. ALL OF THE ABOVE

32

These monkey antigens (Rh factor) are presented in _______ of humans and absent in the other ______.

85% & 15%

33

Transfusion reaction may cause:

A. Destruction of the transfused cells by hemolysis opsonization
B. Increased phagocytosis
C. ALL OF THE ABOVE

34

The antibodies in cold agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins?

IgM

35

Insulin dependent diabetes mellitus is associated with which of the following hypersensitivity?

Type III

36

Production of auto-antibodies may be due to ________.

A. Emergence of forbidden clone of B cells
B. Production of antibody against sequestered tissues
C. Infection-induced change in the cell receptors
D. ALL OF THE ABOVE

37

Auto-antibodies to double-stranded DNA are typical findings in which of the following disorder?

Ankylosing spondylitis

38

The lack of immune response for self-antigen in the fetus is caused by _________.

A. Deletion of self reactive cells
B. Inactivating the cell (anergy)
D. Both A & B

39

In secondary responses the antibodies of which of the following classes of immunoglobulin is detected first?

IgM

40

Which of the following is an antigen presenting cell?

Platelets

41

Which of the following components of the complement primarily undergoes activation in the alternative complement pathway?

C3

42

Type II hypersensitivity reactions involve production of ________.

IgG & IgM

43

B cells are responsible for which allergies?

A. Asthma
B.Anaphylaxis
D. BOTH A & B

44

Example/s of physiologic barrier/s to infection?

Oil and Skin

45

Nonspecific host defense is associated with ______.

Saliva

46

These leucocytes have no identifiable membrane markers, can fight against cancer and belong to innate immunity.

Natural Killer Cells

47

This antibody has the lowest percent in blood circulation and has harmful effect.

IgE

48

Interferon (IFN) can interfere with viral infection. Interferon is a protein made by viral infected cells that bind to adjacent cells, and make them to be resistant to viral infection.

FALSE

49

IFN y can be produced by which on of the following cells?

Macrophages

50

Some microbes may produce peptide antigens that are similar to and cross react with , self antigen. Immune response attacks against these self antigens and produce antibodies that can cross react with tissues. These finding are based on _______.

Theory of Sequestered antigens

51

Prevalance of MS is _______ in tropical, and _____ in North Europe, and Central USA.

Low, High

52

Immunosupprasive strategies for prolongation of allograft

Antigen specific Immunosuppression