Immunology Exam 3

Question 1

Mechanism/s for cell damage in type II hypersensitivity

Answer 1

A. Classical complement cascade
B. Natural Killer Cells
C. Opsonization
D. ALL OF THE ABOVE

Question 2

Incompatible blood transfusion could induce a hemolytic reaction that results in intravascular lysis of the RBC’s and release of _______ from lysed cells.

Answer 2

HEMOGLOBULIN

Question 3

Production of _____ anitibodies may be due to…

Answer 3

A. Emergence of forbidden clone of B cells
B. Production of antibody against sequestered tissue
C. Indirection -induced change in the cell receptors
D. ALL OF THE ABOVE

Question 4

The lack of immune response for self-antigens in the tissue is caused by:

Answer 4

A. Deletion of self reactive cells
B, Inactivating the cell (anergy)
D. A & B

Question 5

This tolerance is unresponsive to self-antigens (all the endogenous antigens).

Answer 5

Natural Tolerance

Question 6

Function of T suppressors cells is important in suppression.

Answer 6

True

Question 7

Antibodies against antibodies called _________.

Answer 7

Anti-idiotype-antibody

Question 8

In Graves’ disease, antibodies blood, the TSH (thyroid stimulating hormone) receptors on the thyroid gland.

Answer 8

True

Question 9

Which of the following autoimmune disease is associated with butterfly rash on the face?

Answer 9

Systemic lupus (SLE, Red wolf)

Question 10

Which of the following factors is/are involved in insulin dependent diabetes mellitus autoimmune disease?

Answer 10

A. Infection
B. HLA gene
C. A & B

Question 11

Which one of the following biochemical/s is/are going to be reduced in Hashimoto’s Thyroiditis?

Answer 11

Thyroxin

Question 12

Which of the following is called rheumatoid factor?

Answer 12

IgM-antibody against F-c portion of a patient’s own IgG

Question 13

Auto-antibodies in double-strained DNA are typical findings in which of the following disorders?

Answer 13

Do not have an answer here, choices: 
A. Rheumatoid arthritis 
B. Systemic lupus erythematosus 
C. Diabetes mellitus 
D. Ankylosing spondylitis

Question 14

Multiple sclerosis is associated with which of the following types of hypersensitivity reactions?

Answer 14

III & IV

Question 15

The antibodies in warm agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins?

Answer 15

IgG

Question 16

Allografts of lymphoid tissue are particularly immunogenic because of the high content of

Answer 16

MHC class II expressing cells

Question 17

An example of a type III immune complex disease is

Answer 17

Rheumatoid Arthritis (RA) and Scleroderma (SLE)

Question 18

The localized reactions to injected antigens in the same body site such as booster shoot are called ________

Answer 18

Arthus reaction

Question 19

A positive tuberculin skin test is an example of __________

Answer 19

A delayed type allergy

Question 20

Contact dermatitis is caused by ________

Answer 20

Chemical absorbed by the skin

Question 21

A graft transplanted between individual who are members of different species

Answer 21

Xenograft

Question 22

Factors that affecting the immune system and decrease the immune functions are as follow:

Answer 22

A. Chronic disease
C. Emotional stress
D. A & C

Question 23

Patient with severe immunodeficiency disease in both T-cells and B-cells compartment accept an allogenic bone marrow graft.

Answer 23

TRUE

Question 24

Natural antibodies have the following characteristics:

Answer 24

A. Low affinity 
B. Low specificity 
C. Harmless 
D. have some rule for clearing infection 
E. ALL OF THE ABOVE

Question 25

In natural tolerance 95% of apoptosis (PCD) of T-cells found in:

Answer 25

Thymus

Question 26

Central Tolerance is within ________

Answer 26

Thymus

Question 27

Matching: 1. Post-Streptococal (Glomerulonephritis); B 2. Arthus Reaction; C 3. Serum Sickness; A 4. Contact hypersensitivity; D

Answer 27

A. Type III hypersensitive (systemic) B. Immune complex disease C. Type III hypersensitivity (local) D. Type IV

Question 28

T suppressor cells prevent ______ to make antibodies, and also prevent _______ from maturing into T-cytotoxic cells.

Answer 28

B-cells, T cells

Question 29

Preexisting infections can have positive or negative effects on immune response.

Answer 29

TRUE

Question 30

This is an induce tolerance in which an animal will fail to respond to non-self antigens (all exogenous antigens) from outside the body that would normally be immunologic.

Answer 30

Acquired Tolerance

Question 31

Which of the following factors are involved in autoimmune disease

Answer 31

A. Infection B. Hormonal C. Genetic D. ALL OF THE ABOVE

Question 32

These monkey antigens (Rh factor) are presented in _______ of humans and absent in the other ______.

Answer 32

85% & 15%

Question 33

Transfusion reaction may cause:

Answer 33

A. Destruction of the transfused cells by hemolysis opsonization B. Increased phagocytosis C. ALL OF THE ABOVE

Question 34

The antibodies in cold agglutinin type immune hemolytic anemia consist of which of the following classes of immunoglobulins?

Answer 34

IgM

Question 35

Insulin dependent diabetes mellitus is associated with which of the following hypersensitivity?

Answer 35

Type III

Question 36

Production of auto-antibodies may be due to ________.

Answer 36

A. Emergence of forbidden clone of B cells B. Production of antibody against sequestered tissues C. Infection-induced change in the cell receptors D. ALL OF THE ABOVE

Question 37

Auto-antibodies to double-stranded DNA are typical findings in which of the following disorder?

Answer 37

Ankylosing spondylitis

Question 38

The lack of immune response for self-antigen in the fetus is caused by _________.

Answer 38

A. Deletion of self reactive cells B. Inactivating the cell (anergy) D. Both A & B

Question 39

In secondary responses the antibodies of which of the following classes of immunoglobulin is detected first?

Answer 39

IgM

Question 40

Which of the following is an antigen presenting cell?

Answer 40

Platelets

Question 41

Which of the following components of the complement primarily undergoes activation in the alternative complement pathway?

Answer 41

C3

Question 42

Type II hypersensitivity reactions involve production of ________.

Answer 42

IgG & IgM

Question 43

B cells are responsible for which allergies?

Answer 43

A. Asthma B.Anaphylaxis D. BOTH A & B

Question 44

Example/s of physiologic barrier/s to infection?

Answer 44

Oil and Skin

Question 45

Nonspecific host defense is associated with ______.

Answer 45

Saliva

Question 46

These leucocytes have no identifiable membrane markers, can fight against cancer and belong to innate immunity.

Answer 46

Natural Killer Cells

Question 47

This antibody has the lowest percent in blood circulation and has harmful effect.

Answer 47

IgE

Question 48

Interferon (IFN) can interfere with viral infection. Interferon is a protein made by viral infected cells that bind to adjacent cells, and make them to be resistant to viral infection.

Answer 48

FALSE

Question 49

IFN y can be produced by which on of the following cells?

Answer 49

Macrophages

Question 50

Some microbes may produce peptide antigens that are similar to and cross react with , self antigen. Immune response attacks against these self antigens and produce antibodies that can cross react with tissues. These finding are based on _______.

Answer 50

Theory of Sequestered antigens

Question 51

Prevalance of MS is _______ in tropical, and _____ in North Europe, and Central USA.

Answer 51

Low, High

Question 52

Immunosupprasive strategies for prolongation of allograft

Answer 52

Antigen specific Immunosuppression