Immunology - Hypersensitivity of Allergic disease part 2 Flashcards Preview

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Flashcards in Immunology - Hypersensitivity of Allergic disease part 2 Deck (10)
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1
Q

What are the 4 types of hypersensitivity?

A

Type I: Immediate hypersensitivity (allergy)
Type II: Direct cell killing
Type III: Immune Complex
Type IV: Delayed. Slide 4

2
Q

What happens during Type II hypersensitivity?

A

Antibody bind to cell-surface antigens

Causes activation of the compliment system and opsonisation. Slide 5

3
Q

Where are compliment proteins produced?

A

Slide 7

4
Q

What are examples of clinical Type II hypersensitivity?

A

Acute haemolytic transfusion reaction -and drug induced haemolysis. Slide 14

5
Q

How do you manage Type II hypersensitivity?

A

Plasmapheresis and immunosuppression. Slide 19

6
Q

What is Type III hypersensitivity?

A

In the presence of excess antigen, the antibody binds forming immune complexes. Slide 22

7
Q

What is an example of Type III hypersensitivity?

A

Hypersensitivity pneumonitis: Farmer’s lung. Slide 24

8
Q

How do you manage Type III hypersensitivity

A

Decrease inflammation with corticosteroids and decrease the production of the antibody through immunosuppression. Slide 28

9
Q

What is Type IV hypersensitivity?

A

T cell mediated hypersensitivity.

There is an initial sensitisation to the antigen and then is is activated again through primed T cells. Slide 33

10
Q

What is the clinical example of Type IV hypersensitivity

A

Poison Ivy as the molecules interact with the skin cell proteins and are very antigenic. This means if there is reactivation of the exposed T cells a skin reaction will occur. Slide 34

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