Immunotherapy

Question 1

Doxyrubicin (Adriamycin)
Anti-cancer antibiotics - CHEMOTHERAPY

Answer 1

Anti tumor antibiotic - treats leukemia, breast cancer, sarcoma, lymphoma; side effect cardiotoxicity

Question 2

Cisplatin (Platinol)
Platinum

Answer 2

Alkylating agent - treats testicular, ovarian and lung cancers; side effect is nephrotoxicity and ototoxicity

Question 3

Methotrexate (Trexall)
Antimetabolite - CHEMOTHERAPY

Answer 3

Antimetabolite - treats lymphoma; side effect is hepatoxicity

Question 4

Tamoxifen (Nolvadex)

Answer 4

Anticancer HT - Estrogen receptor agonist that treats breast cancer; side effects include MSK pain, hot flashes and osteoporosis

Question 5

Pembrolizumab (Keytruda)

Answer 5

Monoclonal antibody - treats NSCLC; side effects include ‘itis’.
Checkpoint inhibitor

Question 6

Tofacitinib (Xeljanz)
Small molecule inhibitor - TARGETED THERAPY

Answer 6

JAK inhibitor - treats RA and psoriatic arthritis; side effects include URI, GI issues

Question 7

Adalimumab (Humira)
Monoclonal antibody

Answer 7

TNF inhibitor - treats autoimmune diseases; side effects include infection, TB activation, or lymphoma

Question 8

Rituximab (Rituxan)
Monoclonal antibody - TARGETED THERAPY

Answer 8

Monoclonal antibody - treats B-cell lymphoma, CLL and autoimmune diseases; side effects may include T-cell lymphoma (due to destruction of B-cells)

Question 9

Abatacept (Orencia)
Monoclonal antibody/immunosuppressant

Answer 9

Monoclonal antibody that inhibits T-cell activation - treats autoimmune diseases; side effects include infections, nausea, headaches

Question 10

Etanercept (Enbrel)
Monoclonal antibody

Answer 10

TNF inhibitor - treats autoimmune diseases; side effects include infections and malignancies

Question 11

CAR-T cells
Immunostimulant

Answer 11

Immunostimulant that removes T-cells for gene therapy, then transfused back in - treats B-cell cancers (lymphoma, leukemia, multiple myeloma); side effects include cytokine storm or chemotherapy issues

Question 12

Tacrolimus (Prograf)
Cyclosporine (Neoral)
Immunosuppressants

Answer 12

Calcineurim inhibitor that blocks T-cell activation - anti rejection for organ/bone marrow and stem cell transplants; side effects include osteoporosis, delayed healing, increased fracture risk

Question 13

Everorlimus (Zortress)
mTOR inhibitor

Answer 13

Immunosuppressant that blocks targe of rapamycin - treats renal cell carcinoma, transplant rejection; side effects include GI issues, infection, rash, stomatitis

Question 14

Glucocorticoids
Corticosteriods - IMMUNOSUPPRESSANT

Answer 14

Suppresses leukocytes - treats everything; side effects include osteoporosis, MSK pain

Question 15

Mycophenolate mofetil (CellCept)
Azathioprine (Imuran)
Antimetabolites

Answer 15

Inhibits proliferation of T and B lymphocytes - treats renal, liver and cardiac transplants; side effects include GI issues, neuropathy, tremor, headache, lymphoma

Question 16

Interferon Alpha
(Immunomodulator)

Answer 16

Induces apoptosis and stimulates immune system - treats melanoma, hep C, Kaposi, genital warts; side effects include hypotension, thrombocytopenia