Important Pathways/Concepts Flashcards Preview

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Flashcards in Important Pathways/Concepts Deck (15):
1

Endonucleases release oligonucleotides from damaged bases
For bulky, distorting lesions

Nucleotide Excision Repair

2

Base-specific glycosylase removes the altered base. Occurs throughout cell cycle.

Base Excision Repair

3

Newly synthesized strand is proofread. Occurs during G2 phase.

Mismatch Repair

4

Start Codon

AUG

5

Stop Codons

UAA, UGA, UAG

6

CDKs

Inactive, activated by cyclin, phosphorylate other proteins to progress cell cycle

7

Signal Recognition Particle

Cytosolic ribonucleoprotein that traffics proteins from ribosome to rough ER

8

Collagen Types (I-IV)

I: Bone, skin, tendon
II: Cartilage
III: Blood vessels
IV: basement membranes

9

Southern blot

Labels DNA

10

Northern blot

Labels mRNA

11

Western Blot

Labels protein

12

Southwestern Blot

Labels DNA binding proteins (transcription factors)

13

Mosaicism

Genetically distinct cell lines within the same individual
Somatic: mutation arises from mitotic errors after fertilization
Gonadal: mutation only in egg or sperm cells

14

Robertsonian Translocation

Fusing of two long arms at the centromere of acrocentric chromosomes leading to the loss of the short-arms (45 chromosomes total)

15

Ketone Bodies

Produced due to OAA depletion for cerebral energy