Industrial Medicine Flashcards

(34 cards)

1
Q

what was the most deadliest disease in the 1700s

A

smallpox

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1
Q

in 1751, how many people died of smallpox

A

3500

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2
Q

what was the only method at the time to prevent smallpox

A

innoculation (promoted by lady Montague)

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3
Q

what does innoculation involve

A

making a cut, soaking it in pus from the swelling of someone who had a mild form of smallpox

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4
Q

what was the advantage and disadvantage of innoculation

A
  • successful
  • but meant the patient had to catch smallpox which sometimes resulted in death
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5
Q

when was Jenner born

A

1749

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6
Q

when did Jenner publish his findings

A

1798

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7
Q

when did jenner first test the vaccine and with who

A
  • 1796
  • a small boy James Phipps with pus from sores of a milkmaid with cowpox
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8
Q

what did Jenner observe

A
  • heard that milkmaids didn’t get smallpox but got a much milder cowpox
  • using careful scientific methods, Jenner investigated this and proved it was true
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9
Q

why did doctors not like innoculation

A
  • those who did innoculation saw it as threat to livelihood
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10
Q

why did the general public not like the vaccine

A

scared about getting a disease from a cow

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11
Q

when did the smallpox vaccination become compulsory

A

1853

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12
Q

what opposition was there to compulsory vaccination

A
  • groups formed campaigns against it
  • didn’t liked being told what to do by gov.
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13
Q

what did William Woodville claim

A

claimed Jenners vaccination worked little better than innoculation after several deaths in his hospital

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14
Q

in 1800s, how much did the gov. give Jenner to open what

A
  • 10,000
  • vaccination clinic
  • 20,000 more a few years later
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15
Q

when was vaccination made free for infants

16
Q

when and what was Louis Pasteur employed for

A
  • 1857
  • to find explanation for the souring of sugar beet used in fermenting industrial alcohol- his answer was germs
17
Q

what did Louis Pasteur prove

A
  • when air entered the long neck, bacteria were trapped in the long tube
  • If they could not reach the liquid, no souring took place
  • When the flask was tipped and the particles were able to reach the liquid, it would turn sour
18
Q

when was the germ theory published

19
Q

what did what what did the germ theory argue

A
  • it argued that microbes in the air caused decay not the other way round
  • he also suggested that some germs caused disease
20
Q

what did Louis Pasteur publish in 1867

A

evidence proving there was a link between germs and disease, demonstrating that germs caused a disease in silkworms

21
Q

what did Koch use to make bacteria more visible

22
Q

when did koch discover anthrax bacteria

23
Q

when did koch discover cholera bacteria

24
when did koch discover tb bacteria
1882
25
what did koch use to document his discoveries and findings
newly invented photography
26
how did war fuel koch and Pasteurs discoveries
- not friends due to Franco-prussian war - fuelled their discoveries
27
what did kochs discovies enable
other discoveries could be made (how malaria is transmitted)
28
how did koch build on pastures work
- linking specific diseases to the microbe that caused them - technique called microbe hunting
29
what did pasture do after finding out about kochs discovery of what caused anthrax
- 1887 - Pasteur started to compete in the race to find and combat new microbes - - his assistant injected chickens with weekend cholera culture and the chickens survived. They then injected them with new cholera culture and they still survived (immune) - the team produced attenuated version of the anthrax bacteria to make the sheep immune - they showed this in a public experiment in 1881 (also used similar method to find vaccine for rabies)
30
what did Ehrlich discover in 1889
- discovered dyes that could kill the malaria germs
31
when did Ehrlich identify the bacteria that caused syphillis
1905
32
what did erlich and his team try to search for- what did they not want to do
- an arsenic compound that was a magic bullet for syphillis - they hoped it would target the bacteria without poisining the rest of the cells
33
how was Salvarsan 606 discovered
- over 600 compounds were tried but none worked - in 1909, Hata joined the team, he rechecked the results - saw that compound 606 actually worked . First used on human in 1911 under name Salvarsan 606