Infection et ATB

Question 1

Anaérobe + commun dans colon

Answer 1

Bacteroides fragilis

Question 2

dérobe plus commun dans colon

Answer 2

E.coli

Question 3

Dx C.diff

Answer 3

EXOToxine A ELISA (baccille gram +)

Question 4

KT sepsis: germe plus fréquent (3)

Answer 4

75% gram+
#1 Staph epidermis
#2 Staph aureus
#3 Enterocoque

Question 5

KT sepsis ATB empirique

Answer 5

Vanco vu staph epidermidis 80% resistant cloxa

Question 6

The most common cause of cellulitis

Answer 6

is beta-hemolytic streptococci (groups A, B, C, G, and F), most
commonly group A Streptococcus or Streptococcus pyogenes

Question 7

The most common cause of skin abscess

Answer 7

is S. aureus

Question 8

what can cause lymphangitis

Answer 8

Strep pyogenes can cause lymphangitis (puss in lymphatics = pyogenes)

Question 9

Infection nécrosantes 3 germe plus fréquent

Answer 9

Strep A et SARM (exotoxine)
Clostridium (alpha toxine)

Question 10

Peritonite bactérienne spontanée germe plus fréquent

Answer 10

E.coli
Monobactérienne majorité temps

Question 11

ATB pour gangrene gazeuse (1)

Answer 11

PNC

Question 12

ATB de choix pour péritonite bactérienne spontané

Answer 12

Ceftri
et en prophylaxie après un épisode: ipro, TMP-SMX

Question 13

Tx HCV

Answer 13

Ribavirin + sofosbuvir

Question 14

manifs
extra-­‐hépatiques
du
VHC

Answer 14

:
cryoglobulinémie,
lymphome,
GN
membranoproliférative,
thyroïdite,
porphyrie,
lichen
plan,
diabèt

Question 15

Cause #1 infection transplante et Tx

Answer 15

CMV
Tx: Ganciclovir

Question 16

Localisation plus fréquente pneumonie aspi

Answer 16

segment superieur LID

Question 17

Arthrite septique ATB empirique en attendant culture (2)

Answer 17

Ceftri+vanco

Question 18

Arthrite septique germe #1 enfant et adulte

Answer 18

S. Aureus

Question 19

Arthrite septique germe retrouve si anémie falciforme

Answer 19

salmonelle

Question 20

Arthrite septique germe retrouve chez UDIV ou pt avec malpeforant plantaire

Answer 20

Pseudomonas

Question 21

Endocardite germe #1

Answer 21

Staph
si UDIV pensé à pseudo

Question 22

Choc toxique germe plus souvent en cause

Answer 22

Staph aureus (exotoxine)

Question 23

ATB qui couvre pseudo (5)

Answer 23

Tazo
Ceftazidime
Cipro
Genta/tobra
Ok mais ont de la résistance: imipenem et méro

Question 24

Effets secondaire particulier ATB: Cipro

Answer 24

tendinite

Question 25

Effets secondaire particulier ATB: Doxy

Answer 25

photosensibilit.

Question 26

Effets secondaire particulier ATB (2): Genta

Answer 26

nephrotoxique (réversible) et ototoxicité (irréversible)

Question 27

Effets secondaire particulier ATB Vanco (2)

Answer 27

leucopénie et néphrotoxique

Question 28

Effets secondaire particulier ATB Flagyl

Answer 28

neuropathie si usage liong terme

Question 29

ATB qui couvre anaérobe (6)

Answer 29

o Flagyl (couvre seulement les anaérobes, rien autre) o Clinda: plus large spectre que flagyl o Clavulin o PNC o Carbapénems o Macrolide (érythro, clarithro, azithro)

Question 30

ATB qui couvre PAS les BGN (3)

Answer 30

Vanco Clinda Ancef

Question 31

When to give antibiotics after drainage? (4)

Answer 31

• Patients with diabetes, cellulitis, signs of sepsis, bioprosthetic hardware (e.g. mechanical valves, hip replacements)

Question 32

Critère pour Surgical Site Infection (time)

Answer 32

criteria that define SSI as infection related to an operative procedure that occurs at or near the surgical incision within 30 days of the procedure or within 90 days (up 1 year in some references) if prosthetic material is implanted at surgery

Question 33

Wound infection cmb ca nous prend GB pour dx dans notre culture

Answer 33

>10E5 bacteria needed for wound infection, less if foreign body present

Question 34

Wound infection germe gram neg plus fréquent

Answer 34

E.coli

Question 35

Wounds infection anaérobe plus fréquent

Answer 35

B. fragilis: #1 anaerobe in surgical wound infections

Question 36

ICU pneumonia germe plus fréquent (2)

Answer 36

ICU pneumonia: #1 S. aureus (gram + ) #2 pseudomonas (GRAM -), #3: E. Coli

Question 37

KT sepsis tx empiriquement avec banco mais quand on doit ajouté un antifongique d'amble?

Answer 37

Consider adding an antifungal agent if o TPN, prolonged use of ATB, hematologic malignancy, transplant, femoral catheterization, Candida spp colonization

Question 38

Tx empirique fascine nécrosante (3)

Answer 38

Méro/Tazo Vanco Clinda

Question 39

Gangrene Fournier gram ? monogram ou mixed organism

Answer 39

Mixed organisms (GPCs, GNRs, anaerobes)

Question 40

C.diff mécanisme action

Answer 40

Toxin B >> toxin A o Toxin B is essential for the virulence of C. difficile and is more than 10 times more potent than toxin A on a molar basis for mediating colonic mucosal damage. Thus, strains lacking toxin A can be as virulent as strains with both toxins

Question 41

ATB qui couvre ANA Gram + et Gram -

Answer 41

Mefoxin (cefoxitine)

Question 42

Causes de température PO?

Answer 42

1ères 48h: atélectasie, libération cytokines inflammatoires 2-5 jours: infx urinaire, pneumonie, TVP > 5 jours: infection de plaie Abcès se forme à partir de PO7 environ

Question 43

Tx pour HSV/EBV?

Answer 43

Acyclovir

Question 44

Ce qui couvre SARM?

Answer 44

Vanco, linézolide

Question 45

ATB bactériostatiques?

Answer 45

MCS Macro, clinda, suldfa