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Flashcards in Infectious Diseases Deck (18):
1

Antibodies directed against proteinase-3 detected as diffuse granular cytoplasmic staining pattern in neutrophils

cANCA (cytoplasmic anti-neutrophil cytoplasmic antibodies)

2

Antibodies directed against myeloperoxidase with perinuclear or nuclear staining in neutrophils

pANCA (perinuclear antineutrophil cytoplasmic antibodies)

3

First step in the workup of a patient with suspected vasculitis

Exclude other diseases

4

Symptoms suggestive of vasculitis

Palpable purpura, pulmonary infiltrates, microscopic hematuria, chronic inflammatory sinusitis, mononeuritis multiplex, unexplained ischemic events and glomerulonephritis

5

Granulomatous necrotizing vasculitis of the triad of upper and

Wegener's granulomatosis

6

Non-granulomatous inflammation of small arteries and veins including venules, glomerulonephritis, usually with no upper airway involvementand no pulmonarynodules, (+) pANCA

Microscopic polyangitis

7

Asthma, peripheral and tissue eosinophila, extravascular

Churg-Strauss

8

Necrotizing vasculitis, renal and visceral artery involvement with aneurysmal dilatations, no pulmonary artery involvement, associated with Hepatitis B

polyarteritis nodosa

9

Elderly , presenting with fever, anemia, headaches, temporal

Giant cell/temporal arteritis

10

Syndrome characterized by stiffness aching and pain in the muscles of the neck, shoulders, lower back, hips and thighs associated with giant cell arteritis

Ischemic optic neuropathy

11

Y= young female, systemic symptoms, arm claudication,

Takayasu's arteritis (also known as Aortic Arch Syndrome or

12

Child with glomerulonephritis, palpable purpura over the buttocks and lower extremities, gastrointestinal symptoms, arthralgias, and history of recent respiratory infection

Henoch Schonlein Purpura (HSP)

13

Most commonly encountered vasculitis in clinical practice

Cutaneous vasculitis

14

So far the most effective therapy for the systemic vasculitides

Cyclophosphamide

15

Cutaneous vasculitis, arthriti, peripheral neuropathy,membranoproliferative glomerulonephritis, Hepatitis C, cold-, precipitated agglutinins or immunoglobulins

Cryglobulinemic vasculitis

16

Drugs implicated in vasculitis syndromes

Allopurinol, Thiazides, Gold, Sulfonamides, Phenytoin

17

Malar rash, Goltron's papules, erythematous periorbital rash (heliotrope rash), shawl and face rash, mechanic's hands, high creatinine kinase, (+) ANA, (+) anti-Jo-1, anti-SRP and anti-Mi-2

Dermatomyositis

18

Calcinosis, Raynaud's phenomenom, Esophageal dysmotility, Sclerodactyly, Telangiectasia

CREST Syndrome (Limited Scleroderma)