Infectious Diseases

Question 1

How is acute hep B managed?

Answer 1

IT isnt

Question 2

What is rate of chronic hep B if infected at birth?

Answer 2

90%

Question 3

What is given to prevent mother to baby transmission of Hep B?

Answer 3

IVIg
Immunisation
Treatment before delivery
All to reduce viral load

Question 4

How is Hep B treated?

Answer 4

Weekly Pegylated Interferon injections

Daily Tenofovir tablets

Question 5

Is Hep C sexually transmitted?

Answer 5

NO barely

Question 6

What is % of maternal transmission of Hep C

Answer 6

6%

Question 7

What are extra hepatic manifestations of Hep C?

Answer 7

Cryoglobulinaemia
Membranoproliferative glomerulonephritis
Thyroid disease

Question 8

How do you test for Hep C?

Answer 8

HCV antibody

Then RCV RNA on PCR for current infection

Question 9

How many genotypes of HCV?

Which prevalent in UK

Answer 9

6

1-3

Question 10

What complications are screened for in HCV and how?

Answer 10

HCC- AFP and USS

HTN- varices by endoscopy 9OGD)

Question 11

How is Hep C cure demonstrated?

Answer 11

undetectable viral RNA in blood 12 weeks after end of treatment (sustained viral response (SR12))

Question 12

What is treatment for Hep C?

Answer 12

Direct Acting Antivirals (DAAs)

2 different durgs from 2 different classes

Question 13

What are classes of Hep C agents?

Answer 13

Protease inhibitors
NS51 inhibitors
NS5b inhibitors

Question 14

How do HIV tests work?

Answer 14

Antigens and antobodies detected in blood

99% sensitive at 4 weeks

Question 15

What CD4 count constitutes AIDs?

Answer 15

CD4>200 or AIDs defining illness

Question 16

What does HAART constitute?

Answer 16

3 different ARVs

2NRTIs and 1 other