Flashcards in Inflammation Deck (29):
Mast cell activators
Fc cross linking, substance P, CGRP. Degranulation inhibition caused by increased cAMP (B agonists, methylxanthines)
Histamine found in...
Mast cells, basophils, ECL cells, histaminergic neurons.
Effects of histamine
Contracts smooth muscle in bronchi and GI tract. Relaxes arterioles via NO. Increases permeability and sensitisation.
q/11 coupled, PLC, Ca++ inflammation
s coupled, cAMP acid secretion
i/o coupled presynaptic inhibition
q/11, unknown function.
Generation 1 antihistamines
Mepyramine, promethazine. CNS effects
Generation 2 antihistamines
Terfenadine (blocks HERG K+ channel)
Generation 3 antihistamines
dimenhydrinate for motion sickness
cimetidine, ranitidine for ulcers.
induced in inflammation
constitutive; q/11 coupled, IP3, Ca++ and eNOS
migration of leukocytes
Made by mast cell and macrophages. Bronchiole spasmogens, constrict coronary vessels but increase flow elsewhere.
Made by PLA2, rapidly degraded in vivo by acetyl hydrolase
Converted to NAPQI; this is normally conjugated with glutathione, but if not enough, can oxidise thiol groups, killing liver and kidney cells.
Aspirin side effects
Salicylate poisoning, Reye's syndrome, hypersensitivity.
NSAIDS in general
Nephropathy, prolonged gestation, ulceration, bleeding
5-HT is made from...
Antiemetic drug classes and examples
5-HT3 antagonists. Ondansetron.
Muscarinic antagonists. Scopolamine
D2 antagonists. Metaclopramide, phenothiazines
H1 antagonists (non-selective). Mepyramine
mAbs binding TNFa
mAb binding IgE
mAb binding CD52
Inhibiting proliferation; cyclophosphamide, azathioprine mycophenylate.
Leading to destruction of B and T cells - alemtuzumab.
inhibiting activation of T cells - calcineurin inhibitors (IL-2), mTOR inhibitors, IL-2 antibodies.
Ca++ dependent serine/threonine phosphatase. Inhibited by cyclosporin/cyclophilin.
5-HT3 receptor antagonists on GI
decrease mobility, cause constipation.