Inflammation Flashcards Preview

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Flashcards in Inflammation Deck (29):
1

Mast cell activators

Fc cross linking, substance P, CGRP. Degranulation inhibition caused by increased cAMP (B agonists, methylxanthines)

2

Histamine found in...

Mast cells, basophils, ECL cells, histaminergic neurons.

3

Effects of histamine

Contracts smooth muscle in bronchi and GI tract. Relaxes arterioles via NO. Increases permeability and sensitisation.

4

H1 receptors

q/11 coupled, PLC, Ca++ inflammation

5

H2 receptors

s coupled, cAMP acid secretion

6

H3 receptors

i/o coupled presynaptic inhibition

7

H4 receptors

q/11, unknown function.

8

Generation 1 antihistamines

Mepyramine, promethazine. CNS effects

9

Generation 2 antihistamines

Terfenadine (blocks HERG K+ channel)

10

Generation 3 antihistamines

fexofenadine, loratidine

11

H1 antagonist

dimenhydrinate for motion sickness

12

H2 antagonists

cimetidine, ranitidine for ulcers.

13

B1 receptor

induced in inflammation

14

B2 receptor

constitutive; q/11 coupled, IP3, Ca++ and eNOS

15

12 HETE

migration of leukocytes

16

Cysteinyl leukotrienes

Made by mast cell and macrophages. Bronchiole spasmogens, constrict coronary vessels but increase flow elsewhere.

17

PAF

Made by PLA2, rapidly degraded in vivo by acetyl hydrolase

18

Paracetamol toxicity

Converted to NAPQI; this is normally conjugated with glutathione, but if not enough, can oxidise thiol groups, killing liver and kidney cells.

19

Aspirin side effects

Salicylate poisoning, Reye's syndrome, hypersensitivity.

20

NSAIDS in general

Nephropathy, prolonged gestation, ulceration, bleeding

21

5-HT is made from...

tryptophan

22

Antiemetic drug classes and examples

5-HT3 antagonists. Ondansetron.
Muscarinic antagonists. Scopolamine
D2 antagonists. Metaclopramide, phenothiazines
H1 antagonists (non-selective). Mepyramine

23

mAbs binding TNFa

Infliximab, adalimumab

24

mAb binding IgE

Omalizumab

25

mAb binding CD52

Alemtuzumab

26

Immunosuppressive drugs

Inhibiting proliferation; cyclophosphamide, azathioprine mycophenylate.
Leading to destruction of B and T cells - alemtuzumab.
inhibiting activation of T cells - calcineurin inhibitors (IL-2), mTOR inhibitors, IL-2 antibodies.

27

Calcineurin

Ca++ dependent serine/threonine phosphatase. Inhibited by cyclosporin/cyclophilin.

28

5-HT3 receptor antagonists on GI

decrease mobility, cause constipation.

29

clavulanate blocks...

A,C and D beta - lactamases