Flashcards in Inflammation Deck (59)
Enumerate chemotactic agents
Platelet Activating Factor
Bacterial Derived N-Formyl peptides
Give the 2 major opsonins
Fc fragment of IgG
Non-opsonic phagocytosis involves ____ wich recognizes ____
Give (5) Lysosome enzymes
Bacterial Permeability Protein
Major Basic Protein
(3) Leukocyte secretions during chemotaxis and phagocytosis
Oxygen-derived active metabolites
Arachidonic acid metabolism products
Enumerate vasoactive amines mediating inflammation
Richest source of histamine
Principal chemical mediator producing interendothelial gaps in venules
Where is serotonin produced?
Platelets and enterochromaffin cells of the GI tract
What forms the MAC?
What are the effects of kinin activation?
What are the effects of bradykinin release?
Increase vascular permeability
Contraction of smooth muscle
What produces platelet activating factor?
What are the effects of PAF?
vasoconstriction, bronchoconstriction, platelet activation
What are the main cytokines? and what cells produce them?
TNF. IL-1; macrophage
What are the local vascular endothelium effects of TNF and IL-1?
Increase expression of leukocyte adhesion molecules
Production of IL-1
What are the local effects of TNF and IL-1 on leukocytes?
activation, production of cytokines
What are the local effects of TNF and IL-1 on fibroblasts?
Proliferation, increase collagen synthesis
What are the major types of chemokines?
Systemic effects of TNF and IL-1 include
increase of acute phase proteins
T/F Chronic inflammation can be caused by autoimmunity
Induced by parasites or allergic reaction;
Mediated by IgE
Involvement of Major Basic Protein
[Identify] Differentiated plasma cells that produce antibodies
What facilitates macrophage activation leading to epithelioid, multinucleate giant cell formation in granulomatous response?
foreign body granuloma is a.k.a
non-hypersensitivity type granuloma
immune granuloma is a.k.a
hypersensitivity type granuloma
The ff conditions produce an immune granuloma due to impairment of T-cell mediated immunity EXCEPT
a. miliary TB
b. lepromatous leprosy
D; Sarcoidosis produce granuloma because there are no identifiable antigens
Which of the following granulomatous conditions can a central abcess be observed
b. Parasite infection
c. Cat-scratch bulla
C; TB- central caseation; parasites - eosinophilia
What are the effects of defective inflammation?
Delayed wound healing
Increased susceptibility to infections
How much change in temperature should be observed to say that one has fever?
1-4 degC inc
What are the chemical mediators cause fever?
TNF, IL-1 and IL-6; indirectly by PGE2 synthesis
What chemicals mediate leukocytosis?
Enumerate (3) Acute phase proteins
C-reactive protein, fibrinogen, Serum amyloid A
IL-1 or TNF
T/F albumin and transthyretin promote acute phase inflammation
F; they are negative acute phase proteins
Mitogenic Growth Factor
Epidermal growth factor
migration and proliferation of fibroblasts, smooth muscle
cells, monocytes; proinflammatory properties
Platelet Derived Growth Factor
[Identify] Growth factor for angiogenesis,
wound repair, development (skeletal muscle,
lung maturation, hematopoiesis)
Fibroblast growth factor
[Identify] growth inhibitor to most epithelial types, stimulates chemotaxis and production of collagen and
fibrinectin cells, inhibit collaged degradation;
Transforming Growth Factor B
[Identify] vascular permeability factor, promote blood vessel formation in early development (vasculogenesis
Vascular Endothelial Growth Factor
[Identify] growth factor for mediation of inflammation and immune response
what is the hallmark of healing?
Can mediate all steps in angiogenesis
a. IL-1, TNF
Cause both angiogenesis and increased vascular permeability
a. IL-1, TNF
D or E
The following impair wound healing EXCEPT
a. Glucocorticoid therapy
c. Radiation exposure
d. Vitamin C
How does glucocorticoid therapy impair wound healing?
Steroids inhibit TGFB, decreasing fibrosis
Enumerate vasoactive mediators
Enumerate Chemotactic factors
Lipooxygenase products; LTB4
PMNS, Platelets, Mast cells
a. Acute inflammation
b. Chronic inflammation
Products of COX1
Products of COX2
What is the function of thromboxane?
Vasoconstrictor, platelet aggregator
Histamine and serotonin
C3a and C5a (by liberating vasoactive
amines from mast cells)
Leukotrienes C4, D4, E4
Increased vascular permeability
TNF and IL-1
Chemotaxis, leukocyte recruitment and
IL-1 and TNF