Inflammation And Immunology Basics

Question 1

What does it mean when you describe a chronic disease as progressive?

Answer 1

Do not resolve and get worse over time.

Question 2

What can sustained tissue inflammation in chronic conditions cause?

Answer 2

Comorbidities such as pain, behaviour disorders and fatigue.

Question 3

What happens to the incidence of chronic disease with age?

Answer 3

Increases with age, 85% of people over 85 have 2 or more chronic conditions.

Question 4

What is the craic with cures for chronic conditions?

Answer 4

They are are and relapse it common

Question 5

What develops in the body during inflammation?

Answer 5

Tolerance due to tissue healing and immune checkpoints

Immune response

Question 6

What is inflammation?

Answer 6

The response of the immune system to an insult

Question 7

What is inflammation characterised as?

Answer 7

Redness

Heat

Swelling

Pain

Dysfunction

Question 8

What is the purpose of inflammation?

Answer 8

Alter the immune system to danger and triggers immune response and healing.

Question 9

What happens when inflammation is sustained?

Answer 9

Chronic disease

Comorbidities

Question 10

What is an allergy?

Answer 10

Caused by inappropriate immune responses to harmless environmental stimuli.

Question 11

What is the immune system?

Answer 11

Defence against pathogens

Question 12

What are the 2 systems of the immune system?

Answer 12

Innate immune cells

Adaptive immune cells

Question 13

What are innate cells?

Answer 13

Rapid but non-specific

Question 14

What are adaptive cells?

Answer 14

Slow but specific

Question 15

What are the 2 classes of lymphocytes in innate immunity?

Answer 15

B cells

T cells

Question 16

What is the function of B cells?

Answer 16

Produce and secrete antibodies

Humoral immunity

Question 17

What is the function of T cells?

Answer 17

Express surface receptors and kill target cells or provide help for B cells/other T cells.

Cellular immunity

Question 18

Where do immune cells come from?

Answer 18

Derived from haematopoietic stem cells in the bone marrow

Question 19

Where do b cells develop?

Answer 19

Bone marrow

Question 20

Where do T cells develop?

Answer 20

Thymus

Question 21

Where do mature B and T cells chill?

Answer 21

Circulate in the blood and lymphatics

Question 22

What are myeloid cells?

Answer 22

Found in all tissues, they are first responders when issues are inflamed.

Question 23

What are tertiary lymphoid tissue?

Answer 23

Loosely organised tissue which could be the residential tissue memory.