Info

Question 0

Effects of alpha2 antagonist

Answer 0

Dec BP w/o increasing the heart rate
CAUSE: 1st dose syncope

Tx for: HTN and urinary retention due to BPH

Question 1

Methyldopa is a prodrug that must be converted 1st to

Answer 1

Alpha-Methylnorepinephrine

Question 2

An irreversible alpha1&2 blocker that is used before operation for pheochromocytoma

Answer 2

Phenoxybenzamine

Question 3

A reversible alpha1&2 blocker that is used to manage HTN due to pheochromocytoma

Answer 3

Phentolamine

Question 4

Ion channel type (channel-linked receptor)

2 types

Answer 4

Receptor operated(ligand gated)

Voltage operated

Question 5

Receptors for many hormones and slow transmitters

Answer 5

G CHON coupled receptor (metabotropic receptors)

Question 6

Potency depends on

Answer 6

Affinity and efficacy

Question 7

The rel bet receptor occupancy and its ability to initiate a response

Answer 7

Efficacy

Question 8

The observable response can be described only in terms of an all or none event

Answer 8

Quantal response

Question 9

Indicates potential variability of responsiveness among indvls
-info regarding safety

Answer 9

Quantal dose response curve

Question 10

Therapetic index aka

Answer 10

Margin of safety

Question 11

The ratio of the lethal doses to 50% of the population over the median effective dose

Answer 11

Therapeutic index

Question 12

Excitatory transmitter of the brain and smooth muscles

Answer 12

NE

Question 13

Released fron inhibitory neurons

Answer 13

5-HT

Question 14

Inhibitory NT of the brain

Answer 14

GABA

Question 15

Thought to be imp in learning, memory and brain fnxns

Answer 15

Excitatory amino acid

Glutamate

Question 16

Ex of opioids that in time of stress and pain , they act at opiate receptors to relieve pain

Answer 16

Endorphins
Enkephalins
Dynorphins

Question 17

Principal transmitters if ANS

Answer 17

Ach and NE

Question 18

G CHON coupled receptors causing:

Answer 18

Activation of phospholipase C (IP3 and DAG)
Inh adenylate cyclase
Activation of K channels or inh Ca channels

Question 19

Muscarinic receptor

Producing slow excitation of ganglia

Answer 19

M1 receptor (neural)

Question 20

Muscarinic receptor

Causing dec in cardiac rate and force of contraction

Answer 20

M2 receptor (cardiac)

Question 21

Muscarinic receptor

Causing secretion, contraction of visceral smooth muscle, vascular relaxation

Answer 21

M3 receptor (glandular)

Question 22

Activates phospholipase C, thus producing IP3 abd DAG

Answer 22

Alpha1

Question 23

Inhibit adenylate cyclase, thus decreasing cAMP fmation

Answer 23

Alpha 2

Question 24

Stimulates adenylate cyclase, thus inc cAMP fmation

Answer 24

All types of beta receptors

Question 25

Shows no rebound anxiety on discontinuance, does not potentiate CNS depressant effects of conventinal sedative-hypnotic and TCA's

Answer 25

Buspirine

Question 27

Accumulation of anxiety and tension w/c leadsto emotional changes and abnormal behavior

Answer 27

Neurosis

Question 28

has fewer ADR than carbamazepine

Answer 28

oxcarbazepine

Question 29

inc plasma conc of phenytoin and valproic acid conc but dec levels of carbamazepine

Answer 29

Felbamate

Question 30

effective as an adjunct against partial and GTC seizure

Answer 30

GABAPENTIN

Question 31

analog of GABA but not acting on GABA receptor; antiepileptic affect is poorly understood

Answer 31

GABAPENTIN

Question 32

a sulfonamide derivative effective against partial and GTC seizures

Answer 32

zonisamide

Question 33

terategenic effect of valproic acid

Answer 33

spina bifida