Moa

Question 0

Competitive antagonist of BZD at GABAa receptor

Answer 0

Flumazenil

ALT: doxopram, nicetamide

Question 1

Has a GABA mimetic activity by acting in the BZD receptor at GABA receptor CI complex, thus prolonging the inhibitory effects of GABA

Answer 1

Benzodiazepines

Question 2

Enhance GABA’s acxn by binding to a different site on the GABA receptor-chloride channel, but less specific than BZD

Answer 2

Barbiturates

Question 3

Partial agonist at brain 5-HT1a receptor

Answer 3

Buspirone

For generalized anxiety stage

Question 4

Not a BZD but act on the same site as BZD

Answer 4

Zolpidem

-pure hynotic acxn

Question 5

Enhances GABA at GABAa receptor,
Inhibits the ability of glutamate to open the cation channel assoc w/ NMDA(N-methyl-D-Aspartate) subtype of glutamate receptor

Answer 5

Alcohol

Question 6

H1 receptor antagonist

Answer 6

Antihistamine

Question 7

Inhibition of phosphodiesterase thus inc cAMP; inc Ca permeability; blocks adenosine receptors

Answer 7

Methylxanthines

+ chrono and inotropic effects on heart

Question 8

Stops MAO, inc rel. of NE

Answer 8

Amphetamines

Question 9

Has the ability to to have vasoconstriction by itself; potentiates and prolongs CNS and peripheral acxns of cathecolamine

Answer 9

Cocaine

-intense euphoria

Question 10

Inhibits reuptake of DOPA, SE and NE

Answer 10

PCP “angel dust”

-Analog of ketamine

Question 11

Interacts w/ several 5HT receptor subtypes in the brain

Answer 11

LSD

-w brilliant color SE

Question 12

Inc reuptake of Ne into adrenergic nerve endings and dec the rel of NE; alters cellular conc of IP3

Answer 12

Lithium

Question 13

Activate the myocardial beta1 receptor and thus inc the force of contraction of the failing heart; inc CO

Answer 13

Dopamine and dobutamine

Used in CHF

Question 14

Displace NE from presynaptic terminals and bind to adrenergic receptors

Answer 14

Mixes sympathomimetics

Question 15

Decreases catecholamine release (reuptake to the vesicles then replace NE)

Answer 15

Guanethidine

Question 16

Depletes catecholamines

Answer 16

Reserpine

Question 17

Competitive cholinesterase antagonist

Answer 17

Edrophonium

Question 18

Compete w/ Ach for the active site of the enzyme

Answer 18

Carbamates

Question 19

Have a high affinity for the active site of the enzyme (cholinesterase inh)

Answer 19

OrganoPO4

Question 20

Block nicotinic receptors both in the sympathetic and parasympathetic ganglia

Answer 20

Ganglionic blockers

Question 22

Inhibits uptake and release of NE from brain synapse but does not influence GABA uptake; blocks Na channels in the brain, also potentiates acxn of GABA

Answer 22

Carbamazepine

Question 23

potentiates the inhibitory acxn effects of GABA; blocks excitatory responses induced by glutamate

Answer 23

phenobarbital

Question 24

inactivates Na channels (anticonv)

Answer 24

lamotrigine

Question 25

has a weak effects on Na channels and little effect on GABA

Answer 25

Felbamate

Question 26

similar to carbamazepine and phenytoin; potentiates inh effect of GABA by acting at different receptor from BZD or barbi site

Answer 26

topiramate

Question 27

inhibits GABA uptake

Answer 27

tiagabine

Question 28

inhibits GABA-T in the brain

Answer 28

valproic acid

Question 29

reduce T-type Ca currents in thalamic neurons

Answer 29

oxazolidinediones

Question 30

most effective in status epilepticus

Answer 30

diazepam

Question 31

also used in status epilepticus

Answer 31

alprazolam

Question 32

used in absence seizure, infantile spasm, myoclonic seizure, and atonic seizure

Answer 32

clonazepam

Question 33

adjunct medication in comples partial seizure

Answer 33

clorazepate

Question 34

used in infantile spasm aand myoclonic seizure

Answer 34

nitrazepam

Question 35

diminish the depolarizing acxn of bicarbonate ions moving out of neurons via GABA receptor ion channel

Answer 35

acetazolamide