Innate immunity 1 Flashcards
(25 cards)
continually shed and renewed
stratum corneum
components of the stratum corneum
dead keratinocytes keratin ceramides free fatty acid cholesterol
Skin:Bacterial colonization is prevented by other factors
Perspiration(sweat)
Sebaceous glands
The respiratory tract is protected from infection by:
SILYA EC,ML(gmpro),TRAPPM,Mucocillary escalator
• ciliated epithelial cells
• mucous layer, glycosylated mucous proteins
• trap particulate matter
• mucociliary escalator
Elevator function is decreased by
HALO-HALOCOKE=-SO2(co2?)=smoking/cold air
• halothane, cocaine, and sulfur dioxide are toxic to epithelial cells.
• Smoking or inhalation of toxic fumes
• cold or dry air
• inherited syndrome characterized by impaired transport and the abnormal structure of cilia.
• Primary ciliary dyskinesia (PCD)
Can survive stomach acid
H. pylori
found in the intestine and also toxic to bacteria
Bile salts
Acids in the vaginal mucosa are produced by
Lactobacilli
risk of vaginal infection is increased by
increased urine pH
reduced Lactobacillus population
molecules that are shared by most pathogenic bacteria
and some viruses.
Pathogen-associated molecular
patterns (PAMPs)
constituents of microbial cell walls, single-stranded and double-stranded nucleic acids, or unmethylated deoxyribonucleic acid (DNA).
Pathogen-associated molecular
patterns (PAMPs)
different mechanisms of PAMPS
- Serum complement components
- Receptors on leukocytes and tissue cells
- Acute phase proteins
Peptidoglycan
DOG(+)
Gram positive bacteria
Lipopolysaccharide
POPO(-)
Gram negative bacteria
Lipotechoic acids
Tech(+)
Gram positive bacteria
Flagellin
Flag
bacteria
Lipoarabinomannan
RAB My Back
Mycobacteria
Beta 1,3 glycan
Bata 1,3 glycan
Fungi
Respiratory synctial virus(RSV)
rs
Viruses
Double stranded RNA
Double s
ViruSeS
Lipopeptides
Popep my co(+)
MYco-plasma
Unmethylated CpGDNA
DNAsipag
CpGDNA(cytosine phosphate guanine)
Bacteria
PROFILIN-LIKE molecules
Toxic profile
Toxoplasma