Innate immunity 2

Question 1

How many serum proteins are there in complements

Answer 1

nine serum proteins

Question 2

produces proinflammatory factors that are

chemotactic for phagocytic cells

Answer 2

SerComComp=chemotactic

SERUM COMPLEMENT COMPONENTS

Question 3

Complement fragments coat bacteria to create____ and promote ______

Answer 3

opsonin and promote phagocytosis

Question 4

antigen–antibody complexes in an adaptive immune

response

Answer 4

( classical pathway)

Question 5

By interaction with molecules (e.g., zymozan) on microbial surfaces

Answer 5

Alt character si zymosan/ microbial surfaces

alternative complement activation pathway

Question 6

complement activation pathway where proteins bind to sugars

Answer 6

(mannose-binding

lectin (MBL) pathway

Question 7

proteins that bind to sugars

Answer 7

Lectin

Question 8

produced by the liver during inflammation

Answer 8

cute liver during inflammation

ACUTE PHASE PROTEINS

Question 9

Collectins

Answer 9

family of lectins

Question 10

multi-meric proteins with a “flower bouquet” or an “Xlike” structure

Answer 10

MBL

Question 11

where in the microbe does MBL react with

Answer 11

terminal MF molecules

terminal mannose/fructose molecules

Question 12

Collectins include

Answer 12

MBLB
MBL-most studied
bovine conglutinin
Lung surfactants A and D
Bovine collectin 43

Question 13

MBL circulates in a complex with ____ and ____

Answer 13

MBL-associated serine protease 1(MASP1)

MBL-associated serine protease 2(MASP2)

Question 14

MBL or MASP activates which complements

Answer 14

dynamite tea activated

C2 and C4 complements

Question 15

MBL or MASP creates

Answer 15

c3 convertase thru activation of c2 and c4

Question 16

Oligomers of triple-helical molecules

Answer 16

Collectin

Ligo 3h

Question 17

complement fragment that binds to bacterial PAMPs and acts as an opsonin

Answer 17

C3b

C3B acts as an opsonin

Question 18

release of histamine and pharmacologic mediators from mast cells and basophiles

Answer 18

MAst c3lls & BA5ophils

C3a and C5a

Question 19

chemoattractants for phagocytic cells

Answer 19

attractants

ANAPHYlatoxins

Question 20

increases capillary permeability and fluid leaks into tissue
&
reduces fluid levels in the vessels and precipitates bacteria, rendering them more susceptible to phagocytosis

Answer 20

capperleaks

HIStamine

Question 21

create a membrane attack complex that inserts a “tube-like”

structure through the bacterial membrane

Answer 21

C5b, C6 and C7-9

Question 22

bind lipoteichoic acids, endotoxins from Gr (-)bacteria, and peptidoglycans
from Gr(+) bacteria

Answer 22

Scavenger receptors

Question 23

• mannose or fructose in the terminal sugars of bacterial glycoproteins

Answer 23

Carbohydrate receptors

Question 24

present on lymphocytes, macrophages, and dendritic cells play a more
important role in innate immunity.

Answer 24

present in LMD important role

Toll-like receptors (TLRs)

Question 25

peptidoglycans of Streptococcus and Staphylococcus

Answer 25

TLR-2

Question 26

proteins of bacterial flagellae

Answer 26

TLR-5

Question 27

activate intracellular signaling

Answer 27

PAMP & receptor interaction

Question 28

synthesis of cytokines that activate both the innate and adaptive immune system

Answer 28

PAMP & receptor interaction