Insomnia Flashcards

(40 cards)

1
Q

What symptoms are typical of daytime impairment in insomnia?

A

Fatigue, depressed mood, irritability, general malaise, and cognitive impairment.

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2
Q

What differentiates insomnia disorder from simple sleep disturbance?

A

Insomnia disorder includes daytime impairment; sleep disturbance without it does not qualify.

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3
Q

How is insomnia categorized based on duration?

A

Short-term: < 3 months; Chronic: ≥ 3 months, several days/week.

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4
Q

What commonly triggers short-term insomnia?

A

Stressful events or changes in sleep (e.g., illness, childbirth, financial difficulties, environmental disturbance).

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5
Q

What tool can help evaluate sleep patterns in insomnia?

A

A sleep diary (kept for 1–2 weeks).

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6
Q

What are some key recommendations for good sleep hygiene?

A

Avoid napping, caffeine, alcohol; use the bed only for sleep/intimacy; exercise early in the day; relax before bed.

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7
Q

What is the first-line treatment for both short- and long-term insomnia?

A

Cognitive Behavioural Therapy for Insomnia (CBTi).

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8
Q

When might hypnotic medications be considered in short-term insomnia?

A

When daytime impairment is severe and insomnia is likely to resolve soon.

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9
Q

Which hypnotics are preferred for short-term use?

A

Non-benzodiazepine hypnotics (Z-drugs).

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10
Q

What age group should avoid hypnotics, if possible?

A

Older adults (>65 years).

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11
Q

For how long should hypnotics be prescribed?

A

Short course (preferably <1 week; max 2 weeks).

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12
Q

What is the risk of long-term hypnotic use?

A

Tolerance, dependence, withdrawal, and rebound insomnia.

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13
Q

What are examples of Z-drugs?

A

Zolpidem and zopiclone.

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14
Q

What antihistamine is used OTC for insomnia, and what are its issues?

A

Promethazine hydrochloride—can cause next-day drowsiness and antimuscarinic effects.

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15
Q

When is melatonin recommended?

A

For adults >55 years with short-term insomnia or jet lag; max treatment: 13 weeks.

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16
Q

What are signs of benzodiazepine withdrawal?

A

Insomnia, anxiety, tremor, tinnitus, perceptual disturbances.

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17
Q

What is the approximate equivalent of diazepam 5 mg in other benzos?

A

Nitrazepam 5 mg, Clobazam 10 mg, Oxazepam 10 mg, Temazepam 10 mg, Lorazepam 0.5 mg, Chlordiazepoxide 12.5 mg.

18
Q

What is the preferred hypnotic for anxious dental patients?

19
Q

What medications should be avoided in benzodiazepine withdrawal?

A

Beta-blockers, antidepressants, antipsychotics (unless absolutely necessary).

20
Q

What are examples of short-acting benzodiazepines used as hypnotics?

A

Temazepam, Loprazolam, Lormetazepam
(Short duration, little to no hangover effect; higher withdrawal risk)

21
Q

What are examples of long-acting benzodiazepines used as hypnotics?

A

Nitrazepam, Flurazepam
(Prolonged action, risk of next-day sedation; cumulative with repeated use)

22
Q

What are the main indications for benzodiazepine use?

A

First-line for seizures/status epilepticus

First-line for alcohol withdrawal

Sedation during interventional procedures

Short-term treatment of severe anxiety

Short-term treatment of severe insomnia

23
Q

What are the key dose-related adverse effects of benzodiazepines?

A

Drowsiness, sedation, coma, and airway obstruction (especially with overdose).

24
Q

Which patient groups should avoid or receive lower doses of benzodiazepines?

A

The elderly

Patients with respiratory impairment or neuromuscular disease (e.g. myasthenia gravis)

Patients with liver failure (except lorazepam) - Because it is less reliant on hepatic metabolism.

25
Which benzodiazepine is preferred for seizures and why?
Lorazepam (IV) – long-acting and effective.
26
What is flumazenil and when is it not recommended?
A benzodiazepine antagonist. Not recommended in mixed or uncertain overdoses as it may cause seizures.
27
What is the main indication for prescribing Z-drugs?
Short-term treatment of debilitating or distressing insomnia.
28
Are Z-drugs chemically related to benzodiazepines?
No, they are chemically distinct but act on the same GABAA receptor.
29
What are common CNS-related side effects of Z-drugs?
Daytime sleepiness, headache, confusion, nightmares, and (rarely) amnesia.
30
What unique side effects are associated with specific Z-drugs?
Zopiclone: Taste disturbance Zolpidem: Gastrointestinal upset
31
Which patients should avoid Z-drugs entirely?
Those with obstructive sleep apnoea Patients with respiratory depression or muscle weakness
32
How do Z-drugs interact with antihypertensives?
They enhance the hypotensive effects.
33
What effect do P450 inhibitors and inducers have on Z-drugs?
Inhibitors (e.g. macrolides): Increase sedation Inducers (e.g. phenytoin, rifampicin): Decrease effectiveness
34
What is the recommended dose of prolonged-release melatonin for adults aged 55 and over with insomnia?
2 mg orally once daily, 1–2 hours before bedtime and after food, for up to 13 weeks.
35
What are common musculoskeletal side effects of prolonged-release melatonin?
Arthralgia and back pain.
36
What are common nervous system-related side effects?
Headache.
37
What gastrointestinal adverse effects can occur with melatonin?
Uncommon: Abdominal pain, dyspepsia, dry mouth, nausea Rare: Vomiting, reflux, ulcers, flatulence, halitosis
38
Which antibiotics may increase melatonin levels?
Quinolones — caution advised.
39
How do oestrogens (CHC or HRT) affect melatonin?
May increase melatonin exposure — use with caution.
40
Which drugs may reduce melatonin levels?
Carbamazepine and rifampicin.