Insulin & oral hypoglycemic

Question 1

Sulfonylureas (glyburide, glipizide) MOA

Answer 1

MOA: stimulate insulin release from pancreatic b-cells

Question 2

Sulfonylureas (glyburide, glipizide) S/E

Answer 2

hypoglycemia (imapired nutrition, >60y, ↓renal func), ↑CV mortality, GI
○ Avoid if sulfa allergy

Question 3

Insulin- Very Rapid Acting: Onset, peak, DOA

Answer 3

Lispro, insulin aspart, glulsiline
Onset: 5-15min
Peak: 45-75
DOA: 2-4hr

Question 4

Insulin: Rapid-acting Onset, peak, DOA

Answer 4

Regular
Onset: 30 min
Peak: 2-4hr
DOA:6-8hr

Question 5

Insulin Intermediate: acting Onset, peak, DOA

Answer 5

NPH
Onset: 2h
Peak: 4-12hr
DOA:18-28hr

Question 6

Insulin long acting

Answer 6

Detemir, glargine
Onset: 2hr
Peak: 3-9 or none
DOA: 24hrs