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Pharmacology II - EXAM 1 > Interactions / P450 > Flashcards

Interactions / P450 Flashcards

1
Q

Progesterone is metabolized by 3A4, and should be avoided with what anitfungal medication?

A

Ketaconazole

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2
Q

Rifampin _______ (Increase/decreases) OCP efficacy

A

decreases

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3
Q

Which THREE AEDs may decrease OCP efficacy?

What are THREE non-OCP contraceptive methods to prevent this?

A
  1. Carbamazepine
  2. Phenobarbital
  3. Phenytoin

Alternatives……

  1. IUD
  2. DMPA
  3. Implants
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4
Q

Which ABx potentially decrease ethinyl estradiol concentration?

Which ABx may cause breakthrough bleeding?

A

Tetracyclines and PCNs

Ampicillin

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5
Q

Is Mifepristone a P450 drug?

A

Yes

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6
Q

T/F: Tamoxifen is NOT a P450 drug?

A

False

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7
Q

What anticoagulant does Tamoxifen interact with?

A

Warfarin

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8
Q

Does Tamoxifen interact with ALL Aromatase inhibitors?

A

No, only…..

Anastrozole
Letrozole

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9
Q

Will Tamoxifen interact with Rifampin?

A

Yes

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10
Q

Is it okay to give Toremifene with drugs that may prolong a QT?

A

No

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11
Q

T/F: Fluvestrant interacts with P450 medications

A

False

It has NO P450 interactions

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12
Q

Why should nitrates be avoided when using PDE5 inhibitors to treat ED?

A

Increase in hypotension

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13
Q

Which PDE5 Inhibitor should be avoided with anti-arrhythmics due to an increased risked of QT prolongation?

A

Vardenafil

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14
Q

Why should diltiazem be avoided in patients taking Tamsulosin?

A

Tamsulosin decreases the metabolism of diltiazem

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15
Q

Which TWO AEDs reduce the effectiveness of Tamsulosin?

A

Phenytoin

Carbamazepine

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16
Q

Fluconazole, Verapamil, and Diltiaem all ______ (increase/decrease) silodosin levels?

A

Increase

17
Q

If silodosin is given with PDE5 inhibitors what may occur?

A

Orthostatic Hypotension

18
Q

T/F: Saw Palmetto has the potential to interact with anti-coagulants

A

True

19
Q

Are the anticholinergics used in OAB treatment metabolized by P450?

If yes, which drugs may be contraindicated due to being P450 inhibitors?

A

Yes

Avoid….

Azoles
Macrolides
Cetirizine

20
Q

What is a major concern in giving tolterodine to patients who 2D6 poor metabolizers?

A

Prolonged QT

21
Q

Does Trospium have P450 interactions?

A

No

22
Q

Mirabegron is a CYP2D6 inhibitor…..

Which Beta-Blocker for HTN should be avoided when prescribing this medication?

A

Metoprolol

23
Q

Carbamazepine is a CYP 3A4 _________.

A

Autoinducer

24
Q

Lamotrigine’s half-life is _______ (increased/decreased) by Valproic Acid?

A

Increased

25
Q

What FOUR AEDs will decrease the concentration of Topiramate?

A
  1. Valproic Acid
  2. Phenytoin
  3. Carbamazepine
  4. Lamotrigine
26
Q

Phenytoin will ______ (increase/decrease) concentrations of almost every other AED

A

Decrease

27
Q

Other than AEDs, what additional medications will phenytoin decrease the levels of?

A 
Acetaminophen
Amiodarone
Doxycycline
Furosemide
Metroniadazole
Prednisone
Rifampine
Warfarin
28
Q

A patient currently being treated with doxycylcine for Lyme disease is given Phenytoin, what may happen to the level of doxycycline in their blood?

A

Decrease

29
Q

A patient with a UTI is given ciprofloxacin, what would happen to the levels of phenytoin if it were administered?

A

Decrease

30
Q

Will amiodarone increase or decrease phenytoin levels?

A

Increase

31
Q

Perampanel is a P450 3A4 _______.

A

Substrate

32
Q

Perampanel will ______ (increase/decrease) the effects of OCPs?

A

Decrease

33
Q

If a patient on anti-coagulants is given Phenobarbital, what are you concerned about?

A

Decrease anti-coagulant activity

34
Q

Would you expect the half-life of doxycycline to be longer or shorter if given with phenobarbital?

A

Shorter

For up to 2 weeks after phenobarbital is discontinued

35
Q

Valproic acid will ________ (increase/decrease) henobarbital levels in the serum?

A

Increase

36
Q

T/F: MOAIs prolong the effect of barbiturates

A

True

37
Q

Phenobarbital _______ (increases/decreases) the effect of estradiol by ________ (increasing/decreasing) it’s metabolism

A

Decreases

Increasing

Pharmacology II - EXAM 1 (5 decks)

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