Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology II - EXAM 1 > Mechanism of Actions > Flashcards

Mechanism of Actions Flashcards

1
Q

Modifies mRNA synthesis, binds to estrogen receptors in the cell, dimerize and bind DNA, infleunces gene transcription….

…. is the MOA for what class(es) of medications?

A

Estrogens

Progestins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Are estrogens or progestins primarily responsible for the contraceptive effect in OCPs?

A

Progestins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Does estrogens or progestins stabilize the endometrium?

A

Estrogens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Do estrogens or progestins inhibit FSH release?

A

Estrogens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Do estrogens or progestins thicken cervical mucus?

A

Progestins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Selective progesterone modulator, inhibits folliculogensis, reduces estradiol concentration, and delays follicular rupture……

…..is the MOA for what emergency contraception?

A

Ulipristal Acetate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Inhibiting and delaying ovulation and preventing fertilization…..

…..is the MOA of what emergency contraception?

A

Levonorgestrel

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Progesterone and cortisol receptor antagonist without effects on estrogen receptors…..

…..is the MOA for what emergency contraception?

A

Mifepristone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

5HT receptor agonist at 5HT1A, antagonist at 5HT2a-C and dopamine receptors…..

….. is the MOA for this HRT drug?

A

Flibanserin (Addyi)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Selective estrogen receptor modulators…. antagonist in breast tissue and agonist in the endometirum, bone, liver, and coagulation system….

….is the MOA for this Breast CA treatment?

A

Tamoxifen
Toremifene
Raloxifene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Selective estrogen receptor down regulator which inhibits and degrades estrogen receptors…..

…. is the MOA for this Breast CA treatment?

A

Fulvestrant (Faslodex)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Inhibit aromatase which is in high concentrations in breast cancer cells…..

…. is the MOA for what Breast CA treatment?

A

Anastrozole
Letrozole
Exemestane

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Inhibit phosphodiesterase-5 found in genital tissue, increase smooth muscle relaxation, and incease blood flow……

…. is the MOA for what ED treatment medications?

A

Sildenafil (Viagra)
Vardenafil (Levitra)
Tadalafil (Cialis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Block NE effects on alpha-1 receptors to help relax the prostate and urethra…

… is the MOA for what BPH medications?

A

Terazosin (Hytrin)
Doxazosin (Cardura)
Prazosin (Minipres)

Tamsulosin (Flomax)
Alfuzosin (Uroxatral)
Silodosin (Rapaflo)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Blocks the conversion testosterone to dihydrotestosterone, block alpha-5 reductase….

…. is the MOA for what BPH medications?

A

Finasteride (Proscar)

Dutasteride (Avodart)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Non-selective muscarinic receptor antagonists at M2 and M3…

… is the MOA for what OAB medications?

A 
Oxybutynin (Ditropan)
Tolterodine (Detrol) 
Fesoterodine
Trospium
Solifenacin
Darifenacin (Enablex)
17
Q

Beta-3 agonist that works to relax the detrusor muscle and increase bladder capacity…..

… is the MOA for what OAB medication?

A

Mirabegron

18
Q

Blocks sodium channel with fast inactivation of action potentials….

…. is the MOA of what AED?

A

Carbamazepine (Tegretol)

19
Q

MDH metabolite that inhibits voltage-sensitive sodium channels….

…. is the MOA for what AED?

A

Oxcarbazepine (Trileptal)

20
Q

Blocks voltage-dependent sodium channels at high firing frequencies, Enhances H current, Modulates kainate receptors….

…. Is the MOA for what AED?

A

Lamotrigine (Lamictal)

21
Q

Believed to enhance GABA transmission, inhibit sodium channels, and modulate T-type Ca2+ channels…

… is the MOA for what AED?

A

Valproic Acid (Depakote)

22
Q

Binds reverisble SV2a, modulates kainate receptor activity, reverses inhibition of GABA and glycine gated currents induced by negative allosteric modulators…..

… is the MOA of what AED?

A

Levetiracetam (Keppra)

23
Q

Blocks voltage-dependent Na+ channels at high firing frequencies, increases frequency at which GABA opens Cl- channels, antagonizes glutamate action, inhibits carbonic anhydrase……

…. is the MOA of what AED?

A

Topiramate (Topamax)

24
Q

Blocks, low threshold, T-type calcium channels in thalamic neurons….

…. is the MOA of what AED?

A

Ethosuximide

25
Q

Slows the recovery of Na+ channels….

… is the MOA for what AED?

A

Phenytoin

Fosphenytoin

26
Q

Blocks voltage-dependent sodium and t-type calcium channels…

…. is the MOA of what second-line AED?

A

Zonisamide

27
Q

Enhances slow inactivation of voltage gated sodium channels…..

…. is the MOA of what second-line AED?

A

Lacosamide (Vimpat)

28
Q

Non-competitive glutamate receptor antagonist…..

… is the MOA for what second-line AED?

A

Perampanel

29
Q

Prolong GABA-mediated chloride channel opening…..

… is the MOA for what AED(s)?

A

Phenobarbital

Primidone

30
Q

Increase the frequency of GABA-mediated chloride channel openings, prolongs inhibitory post-synaptic currents….

… is the MOA for what AEDs?

A

Clonazepam (Klonopin)
Diazepam (Valium)
Lorazepam (Ativan)
Midazolam (Versed)

31
Q

Structurally related to GABA, blocks Ca2+ channels, enhances H current, supresses presynaptic vescile release, supresses NMDA receptors…..

… is the MOA for what AED?

A

Gabapentin (Neurontin)

Pregabalin (Lyrica)

32
Q

Interferes with GABA re-uptake site by binding to the uptake carrier….

… is the MOA for what AED?

A

Tiagabine (Gabitril)

33
Q

Irreversible inhibits GABA-transaminase….

…. is the MOA for what AED?

A

Vigabatrin

34
Q

Opens K+ channels….

….. is the MOA for what AED?

A

Ezogabine

35
Q

Blocks voltage-dependent Na+ channels, blocks NMDA receptors and enhances GABA receptors…..

…. is the MOA for what AED?

A

Felbamate (Felbatol)

Pharmacology II - EXAM 1 (5 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions