Intro to Disorders of the Skin Flashcards Preview

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Flashcards in Intro to Disorders of the Skin Deck (26):
1

What are the functions of skin?

Mechanical barrier
Immunological organ
Homeostasis
Sensory and endocrine
Psychological

2

What are the two layers of the dermis?

Papillary and reticular layer

3

What are adnexal structures?

Sebaceous glands, sweat glands, hair follicles

4

What function do melanocytes have?

Create and transfer melanin to keratinized cells

5

What are Langerhans cells?

Dendritic cells found in the epidermis

6

What are the three compartments for pathologic considerations?

Epidermis and skin adnexa
Melanocytic system
Dermis and subcutis

7

What are common nonneoplastic pigmentation disorders?

Freckles (ephelis)
Lentigo

8

What is the difference between freckles and lentigo?

Freckles: increase in the degree of pigmentation (not amount of cells)
Lentigo: increase in the number of melanocytes

9

What is a neoplastic benign disorder?

Melanocytic nevus (mole)

10

What are the three types of melanocytic nevus?

Junctional (D-E junction)
Compound (vertical growth down into dermis)
Intradermal

11

What are two neoplastic malignant disorder of melanocytes?

Dysplastic Nevi
Malignant Melanoma

12

What is important consider when looking at possible neoplastic cells?

Larger than normal nuclei and an increased nucleus/cytoplasm ratio

13

Where is malignant melanoma found?

Skin, mucosa, meninges, uvea of eye

14

What are the four ways to describe a melanoma?

Asymmetry, irregular borders, variations in color, diameter increase

15

What are two types of benign tumors?

Seborrheic keratoses
Fibroepithelial polyp

16

What is characteristic of seborrheic keratoses?

Coin-like waxy
Can be paraneoplastic syndrome

17

What is a fibroepithelial polyp?

Skin tag

18

What are premalignant tumors of the skin?

Actinic keratosis (can lead to squamous cell carcinoma)

19

What does actinic keratosis present like?

Rough sand-papery feel can develop a horn like projection hyper keratosis

20

What are two types of malignant skin tumors?

Squamous cell carcinoma (UV radiation)
Basal cell carcinoma

21

What is a blister?

Separation in epidermis typically with fluid

22

What are the three types of blisters?

Subcorneal
Suprabasal
Subepidermal

23

What are two blistering diseases?

Pemphigus vulgaris
Bullous pemphigoid

24

What is pemphigus vulgaris?

IgG auto reactive antibodies attack desmosome components; shallow so rupture easily; net like pattern; suprabasal blisters

25

What is bullous pemphigoid?

Elderly individuals autoantibodies against hemidesmosome components; sub-epidermal non-acantholytic blisters

26

Difference between desmosomes and hemidesmosomes

Desmosomes: adjacent cell connections
Hemidesmosomes: cell connections to basement membrane