Flashcards in Intro to Disorders of the Skin Deck (26):
What are the functions of skin?
Sensory and endocrine
What are the two layers of the dermis?
Papillary and reticular layer
What are adnexal structures?
Sebaceous glands, sweat glands, hair follicles
What function do melanocytes have?
Create and transfer melanin to keratinized cells
What are Langerhans cells?
Dendritic cells found in the epidermis
What are the three compartments for pathologic considerations?
Epidermis and skin adnexa
Dermis and subcutis
What are common nonneoplastic pigmentation disorders?
What is the difference between freckles and lentigo?
Freckles: increase in the degree of pigmentation (not amount of cells)
Lentigo: increase in the number of melanocytes
What is a neoplastic benign disorder?
Melanocytic nevus (mole)
What are the three types of melanocytic nevus?
Junctional (D-E junction)
Compound (vertical growth down into dermis)
What are two neoplastic malignant disorder of melanocytes?
What is important consider when looking at possible neoplastic cells?
Larger than normal nuclei and an increased nucleus/cytoplasm ratio
Where is malignant melanoma found?
Skin, mucosa, meninges, uvea of eye
What are the four ways to describe a melanoma?
Asymmetry, irregular borders, variations in color, diameter increase
What are two types of benign tumors?
What is characteristic of seborrheic keratoses?
Can be paraneoplastic syndrome
What is a fibroepithelial polyp?
What are premalignant tumors of the skin?
Actinic keratosis (can lead to squamous cell carcinoma)
What does actinic keratosis present like?
Rough sand-papery feel can develop a horn like projection hyper keratosis
What are two types of malignant skin tumors?
Squamous cell carcinoma (UV radiation)
Basal cell carcinoma
What is a blister?
Separation in epidermis typically with fluid
What are the three types of blisters?
What are two blistering diseases?
What is pemphigus vulgaris?
IgG auto reactive antibodies attack desmosome components; shallow so rupture easily; net like pattern; suprabasal blisters
What is bullous pemphigoid?
Elderly individuals autoantibodies against hemidesmosome components; sub-epidermal non-acantholytic blisters