Intro to immune (lecture 6 just now doing the intro woo) Flashcards Preview

HDM Midterm > Intro to immune (lecture 6 just now doing the intro woo) > Flashcards

Flashcards in Intro to immune (lecture 6 just now doing the intro woo) Deck (16):
1

IL-7

common lymphoid progenitor signal

2

pro b and t cells are generated in the

bone marrow

3

digeorge syndrome

thymic hypoplasia or aplasia
hypoparathyroidism
congenital cardiac malformation
degree of immunodeficiency varies on thymus loss
deletion syndrome of 22q11.21 through .23

4

mature naive lymphocytes reside in

the circulation and peripheral lymphoid organs until activated by 1)APCs (t cells) or soluble Ag (b cells)

5

humoral immunity

adaptive defense against EC pathogens
Ab mediated - B cells/ Plasma cells

6

infant recieves ____ Ab from mom through breastmilk

IgA

7

fetus recieves _____ Ab from mom during pregnancy through circulation

IgG

8

cell mediated immunity

adaptive against IC pathogens
T cells and macrophages

9

cd8+ t cells function

kill infected cells (IC defense)
Ag-specific, MHC restricted
excrete granules at target cell - perforin/granzyme b enter cell and activate apoptotic pathways

10

cd4+ t cell function

cytokine secretion to activate macrophages to kill ingested microbes/ inflammation to kill microbers

11

th1 cell

secrete IFN-gamma
activate macrophages and induce IgG production
defense against IC
involved in autoimmune diseases/ tissues damage of chronic infections

12

th2 cell

secrete IL-4, IL-5, IL-13
activate mast cells, eosinophil, induce IgE production, alternative macrophage activation
defense against helminith parasites
involved in allergic diseases

13

th17 cell

secrete IL-17A,F, IL-22
activate neutrophilic, monocytic inflammation
defense against EC bacteria, fungi
involved in autoimmune inflammatory disease

14

IL-12

induces differentiation of t cells to th1 cells

15

passive immunization

intro of Ab or antiserum into naive recipient (does not challenge recipient immune system)

16

active immunization

introduces Ab that provokes immune response