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Flashcards in Intro Deck (10):
1

Immunity refers to

the ability to respond to foreign substances regardless of the physiologic or pathological consequences of such a reaction. Mediated by molecules, cells, tissues

2

Cluster of differentation

Cell surface molecules expressed on various cell types designated by a CD number. Used to define cell types, receptors, ect.

3

Innate immunity

protection against infections that relies on mechanisms that exist before infection, are capable of rapid responses to microbes, and react in essentially the same way to repeat infections

4

Characteristics of innate immunity

rapid response
Not Ag specific, limited diversity
No memory
Stimulates adaptive

5

eosinophils

differentiation signal: IL-15

Combat multi-cellular parasites

Play a major role in atopic disease

6

Basophils

Bi lobed nucleus
non-phagocytic
release pharmocologically active substances contained wihtin granules
associated with atopic disease

7

Mast Cells

Can be stimulated to degranulate by direct injury, chemical, alcohols, and certain antibiotics, cross-linking of IgE receptors or by activated C proteins

Play a key role in the inflammatory process

High affinity receptor: CD23

8

Inflammatory mediators released by mast cells

Granule contents: Immediate - histamine, proteases, heparin, TNF

Membrane-derived: Minutes - prostaglandins, leukotrienes, PAF

Cytokines: hours - IL-1, -3, -4, -5, -6, -8, TNF

9

Natural Killer Cells

Activated by IL-12 (from macrophages), IL-15, Type I IFNs
Secrete IFN-Gamma (activates Macrophages)

Principle mediator of ADAC
CD16+ CD56+

10

Characteristics of Adaptive Immunity

Specificity
Diversity
Memory
Clonal Expansion
Specialization
Contraction and homeostasis
Non-reactivity to self