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Flashcards in Introduction Deck (23):
1

Accuracy

How accurate a test is to give the correct concentration
- analytical, not clinical

2

Precision

Same distance/measurement every time
- could still use if you know systematic error

3

Analytical imprecision

Cannot predict what the error is (random)
- is present in all tests
- large random error will render test nonuseful

4

Analytical specificity

Could measure something not intended, so there is little specificity
- ex: when hemolysis impacts the results of a test

5

Detection limit

Would rather have a lower upper detection limit, than too low a minimum detection limit
- easier to dilute a sample than to concentrate it

6

Which 2 characteristics have little to no systematic error?

Analytical and precision accuracy

7

Interpretation of results is dependent on ________

Reference range

8

How are reference intervals established and what do they indicate?

- 60-120 animals of each species
- young adults, clinically healthy, represent animal population of the region

9

Confidence interval

95% for the population
- 1 in every 20 animals will have a result that is outside the reference interval (even though the animal is healthy)

10

Reference limit

Value of a test that is above or below the reference limit may indicate pathological state

11

Decision threshold

Value of a test that is used to classify as positive or negative for a disease, or used to decide changes in treatments

12

Quality of laboratory results depends on:

- quality of sample
- quality of analysis
- quality of laboratory records

13

What are the 3 components of quality assurance?

- preanalytical errors (quality of sample)
- analytical errors (quality of analysis)
- postanalytical errors (quality of lab records)

14

Sample collection

Preanalytical error
- prep of patient
- collection technique
- collection container
- anticoagulant
- sample volume

15

Sample handling

Preanalytical error
- proper labeling
- appropriate temp
- prompt processing

16

Analytical error

- method appropriate for species
- quality of instruments and equipment
- quality of reagents
- quality of lab technique
- quality control program (assessment of variations on results)

17

Postanalytical errors

- transcriptional errors
- graphic quality of report

18

In-house lab: advantages

- 24hr access
- short turn around time
- fresh sample

19

In-hoes lab: disadvantages

- cost
- maintaining inventory
- training of personal
- quality assurance program
- reference intervals

20

Vet reference laboratory: advantages

- personnel trained
- diagnostic support available
- appropriate reference interval
- more tests available
- cost per sample clear

21

Vet reference lab: disadvantages

- sample may deteriorate
- turn around time is variable

22

Human lab: advantages

Short turn around time

23

Human lab: disadvantages

- reference interval may not be established
- assay methods may not be appropriate
- personnel may not know species variations
- price