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Introduction (Classification & Life Cycles) Flashcards

1
Q

Parasite - Definition

A

an organism baring food and shelter temporarily or permanent and living in or on another organism

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2
Q

Parasite - Types

A

Facultative parasite: both free living and parasite lifestyle e.g. Strongyloides spp.

Obligate parasite: living permanently in a host and cannot live without a host e.g. Trichomonos spp.

Coprozic (spurious) parasites: foreign, pass through alimentally canal without affect.

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3
Q

Clinical Parasitology

A

animal parasites of man and their medical importance.

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4
Q

Parasites - Divisions

A
  1. Protozoa
  2. Helminthes
    a. Roundworms (nematodes)
    b. Flatworms - Cestodes (tapeworm)
    Trematode (fluke)
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5
Q

Parasite vs Host

A

Parasite - living at the expense of the other and harmful

Host - larger organism that harbours a smaller, harmful organism

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6
Q

Host - Classifications

A

1-Definitive host: harbors the adults/ final stages/ sexual stages (♂♀) in the development of parasite e.g. man.

2-Intermediate host: larva stages or Inter mediate stages in the development. E.g. Taenia adult—— man; Larva –— cattle

3-Reservoir host (carrier): the carrier host is well adapted to the parasite and tolerates the infection but serve as source of the infection to other organisms.

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7
Q

Organisms Relationships

A

Symbiosis: permanent association between two organisms

Mutualism: two organisms living together, the two organisms benefit.

Commensalism: Two organisms Living together, one is benefited and the other is not been affected.
When the other organism become affected, then the relationship turns = Parasitism.

Zoonosis: disease of animals but can be transmitted to a man. Ex: Hymenolepis nana.

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8
Q

Protozoa - Classification

A
  • Intestinal
  • Urogenital
  • Blood and tissue
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9
Q

Intestinal Protozoa

A

Entamoeba histolytica
Giardia lamblia
Cryptosporidium

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10
Q

Blood and Tissue Protozoa Diseases

A

Malaria
Toxoplasma
Trypanosoma
Leishmania

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11
Q

Urogenital tract Protozoa

A

Trichomonas vaginalis

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12
Q

Nematodes

A

Roundworms - Ascaris lumbricoides

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13
Q

Cestodes

A

Flatworms - Taenia saginata

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14
Q

Trematodes

A

Flukes - Bilharzia (Schistosomiasis)

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15
Q

Amoebiasis (organism)

A

Entamoeba histolytica

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16
Q

Amoebiasis

A

Mode of locomotion : Pseudopodia (false feet)
Poor sanitation areas

Habitat: in the lumen of the large intestine
Pathogenic: because it can invade intestinal walls

Reservoir: major: humans
minor: dogs, pigs, monkeys

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17
Q

Entamoeba histolytica (morphology)

A

Cyst - infective stage - polluted water and food

Trophozoite - pathogenic stage

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18
Q

Entamoeba histolytica - Life cycle

A

1 . Cyst -infective stage
2 . Enters mouth via contaminated food, water or via human feces as fertilizer
3 . Moves to large intestine and change to trophozoite (pathogenic stage)
4 . Produce lytic enzymes (lysis+ulcer)
5 . Flask shaped ulcer
6 . Can do erosion through BV to liver + other organs

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19
Q

Amoebiasis - Clinical features

A

Dysentery: blood+mucous diarrhea (from flask shape ulcer wall invasion)
Severe abdominal pain
Tenesmus: sense of incomplete evacuation
(the patient at this point should be seeking medical advice)

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20
Q

Amoebiasis - Intestinal complications

A

Peritonitis, appendicitis, Hemorrhage

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21
Q

Amoebiasis - Extraintestinal complications

A

liver (most common) - hepatitis (severe right abdominal pain)
- Fever
- amoebic liver abscess ( inflammation (pus)
- shoulder pain + Toxemic manifestations
Also in lung, skin, and brain

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22
Q

Pus

A

Fluid composed of white blood cells and dead cells that typically forms when your body fights off infection

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23
Q

Toxemia

A

Blood contains toxins produced by body cells at a local source of infection or derived from the growth of microorganisms.
Also called blood poisoning.

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24
Q

Malaria - Reemergence Issues

A

Problems of controlling malaria:

  • inadequate health structures
  • poor socioeconomic conditions
  • increased resistance to anti parasitic drugs
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25
Malaria - Protozoan parasites
Plasmodium falciparum - most widespread and dangerous of the five - if untreated it can lead to fatal cerebral malaria. P. vivax. Plasmodium ovale. Plasmodium malaria. P. knowlesi
26
Malaria - Carrier
Transmission: via female anopheles mosquito
27
Malaria - Reproduction
Malaria parasite is a sporozoan; has 2 reproductive stages 1. Sexual reproduction: in anopheles mosquito 2. Asexual reproduction: in human - host infected with ingested cysts - cysts divide to produce sporozoites - sporozoites enter host cells - cells burst releasing merozoites - merozoites infect new host cells until gamonts produced - gamonds form gametes - gametes fuse to form cysts
28
Sporozoans
- no flagella, cilia, or pseudopodia | - capable of gliding movements
29
Malaria - life cycle
Plasmodium develops in the gut of mosquito and is passed on in the saliva of an infected insect Sporozoites carried by blood to the victim's liver where they form cyst-like structure containing thousands of merozoites After 9-16 days they return to the blood and penetrate the red cells, where they multiply again, progressively breaking down the red cells
30
What correlates to the symptoms of fever and anemia in malaria?
Merozoites moving to bloodstream and penetrating red blood cells thereby breaking down RBCs
31
Paroxysm of fever can occur, why?
If red cells rupture at roughly the same time, a paroxysm (sudden onset) of fever can result due to massive release of toxic substance.
32
Which protozoa are milder forms of malaria and why?
P. malriae, P. vivax, and P. ovale cause milder form of the disease, probably because they invade either young or old red cells, but not both
33
Why is P. falciparum the most dangerous malaria protoza?
Causes persistent high fever and orthostatic hypertension. | Infection can lead to capillary obstruction and death if treatment is not introduced
34
Orthostatic hypertension
Sudden increase in BP when standing
35
Toxoplasmosis - Protozoa
Toxoplasma gondii
36
Toxoplasmosis
Transmission: 1) eating raw, undercooked meat of sheep and cow containing viable trophozoites (bradyzoites) 2) swallowing food and water contaminated with infected cat feces 3) Congenital transmission, through placenta (fatal) especially when infection occurs during pregnancy 4) person to person: ex. By blood transfusion or organ transmission
37
Toxoplasmosis - Clinical features
Hosts: humans Infection - common, asymptomatic - severe in immunocompromised persons Congenital infection - blindness in newborns
38
Helminthes- division
Eukaryota
39
Nematodes
slender, typically less than 2.5 mm long. - smallest nematodes are microscopic - free-living species can reach as much as 5 centimeters and some parasitic species are larger still.
40
Largest nematode in human intestine
Ascaris lumbricoides is the largest nematode (roundworm) parasitizing the human intestine Common among people with low standard of living and among children
41
Ascaris lumbricoides morphology
Adult: in small intestine Egg: infective stage
42
Ascaris lumbricoides - Life cycle
2 phases: lung and intestinal ``` Egg ingested, hatches in duodenum; larvae penetrate intestine wall, enter blood vessels embolize through liver to lungs. ``` They migrate into airspaces, up trachea and are swallowed, They take up permanent adult residence in the small intestine
43
Ascaris lumbricoides - Numbers
small numbers -- asymptomatic large numbers of adults – obstruction, pains - cause malnutrition if in large numbers
44
A. lumbricoides - Clinical symptoms | - lung phase
hemorrhage, inflammation, bacterial infection | high IgE levels may cause allergy-like symptoms such as asthma
45
A. lumbricoides - Clinical symptoms | - intestinal phase
malnourishment, intestinal blockage. | -moves around in response to chemotherapy or fever
46
Cestodes
ribbon-shaped, multi-segmented flatworms - dwell as adults solely in the human small intestine. - larval forms lodge in skin, liver, muscles, CNS, etc.
47
Taenia saginata (Beef tapeworm) - transmission
Human transmission: ingesting raw/poorly cooked infected cow meat Cow transmission: ingesting human feces containing cyst Cattle: Intermediate host
48
Taenia saginata - Morphology
Adult split into 3 parts 1- a head: round and small. It has four suction disks 2- neck: A small, slender neck, about an inch long 3- segmented body
49
Habitat:
- adult in small intestine of man only - Egg in feces - larva stage in muscle of thigh, shoulder, neck and heart of cattle only
50
Teniasis - Symptoms
High infection: diarrhea and consitipation Vomiting Loss of appetite Anemia
51
Trematodes
flattened oval/worm-like animals, no more than a few cm long | distinctive external feature : two suckers, one close to the mouth, and on the underside of the animal.
52
Schistomiasis affects where?
- Disease of venous system | - Flukes reside in abdominal veins
53
Schistomiasis affects which age group most?
Children
54
Schistomiasis - transmission
Direct skin penetration ONLY - Fresh water contaminated with cysts when infected urinate/defecate in water -> Eggs hatch and parasites grow inside snails Snails: Intermediate host
55
Schistomiasis -Life cycle
1. Cercaria transforms into an endoparasitic larva, the schistomule. 2. Schistomules enter the venous circulation from skin and migrate to the lungs 3. They travel through the circulatory system to the heptoportal circulation where they mature into adult worms and mate. 4. Depending on the species, the schistosomes migrate to their final infection site either on the bladder or the intestine where the females begin egg production. These eggs are attached the wall of the lumen. 5. The eggs penetrate the wall of the lumen. 6. Eggs expelled in the feces or urine. 7. The miracidium, liberated from the egg, seek out snail hosts where they enter a sporocyst stage -> cercaria
56
Schistomiasis/Bilharzia -Types
intestinal Schistosomiasis Primary site: GIT Urinary tract Schistosomiasis Primary site: Veins of urinary bladder
57
Intestinal Schistomiasis - effect in body
Damage to the intestinal wall is caused by the host’s inflammatory response to eggs deposited at that site. The eggs also secret proteolytic enzymes that further damage the tissue
58
Urinary Tract Schistosomiasis - effect in body
Organism eggs can induce fibrosis, granulomas, and hematuria
59
Anthroponosis
Infectious disease of humans that can be transmitted naturally to other animals
60
Zoonosis
Parasite infects primarily an animal but can also infect and cause disease in humans.
61
Anthropophillic
Insect preferring animal host over humans

Parasitology (10 decks)

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