Introduction to Pharmacology and Toxicology: Lecture 1 Flashcards Preview

PM2C: Therapeutics and Patient Care: Autumn > Introduction to Pharmacology and Toxicology: Lecture 1 > Flashcards

Flashcards in Introduction to Pharmacology and Toxicology: Lecture 1 Deck (10):
1

What is Pharmacology

The study of the effect of drugs on the function of living systems

2

What is pharmacodynamics?

The effect of the drug on the body- example: Paracetamol- mechanism of action is dependent on the inhibition of prostaglandin synthesis

3

What is pharmacokinetics

The effect of the body on the drug (relates to Absorption, Distribution, Metabolism, Excretion (ADME))

4

What is a drug?

Biologically active compound (other than a nutrient or essential dietary ingredient) taken with the intent to produce a change in the body

5

What is a medicine

A chemical preparation which usually contains one or more drugs that is administered with the purpose of producing a therapeutic effect. Also contains other substances to make them more convenient.

6

What is a drug that activates a receptor called?

Agonist

7

What is a drug that blocks a receptor called?

Antagonist

8

What is a concentration response curve?

Logarithmic scales used to generate concentration response curve

9

What does the word target mean in terms of drug targets?

The molecular recognition site to which a drug will bind- majority are proteins

10

What are the four pharmacological principles?

1. Active ingredient (drug molecules)

2. Selectively bind to certain molecular targets (proteins) to:
- Exert cellular effect
- Exert effect on the system

3. Produces therapeutic effect in a concentration related or concentration dependent fashion

4. Efficacy (usefulness) of medicine is then supported by clinical trials using agreed outcome measures and statistical validation