IS Complement System

Question 1

series of more than 30 soluble and cell bound proteins that enhances host defense mechanisms against foreign cells

Answer 1

Complement

Question 2

coined the term complement

Answer 2

Paul Ehrlich

Question 3

elucidated the nature of complement

Answer 3

Jules Bordet

Question 4

promote opsonization and lysis of foreign cells and immune complexes

Answer 4

Complement

Question 5

may lead to inflammation and tissue damage

Answer 5

Chronic Activation

Question 6

9 protein that are triggered by antigen- antibody combination

Answer 6

Classical Pathway

Question 7

triggered by the binding of complement protein C1q to antibodies that are bound to pathogens or other foreign particles

Answer 7

Classical Pathway

Question 8

main antibody directed mechanism for triggering complement activation, can only be activated by?

Answer 8

IgM,IgG1,IgG2, IgG3

Question 9

why is IgM most efficient?

Answer 9

Multiple binding site

Question 10

synthesized by the liver in exception with C1 components

Answer 10

Complement Proteins

Question 11

recognition unit

Answer 11

C1

Question 12

activation unit

Answer 12

C4, C2, C3

Question 13

membrane attack complex

Answer 13

C5-C9

Question 14

binds to Fc region of IgM and IgG

Answer 14

C1q

Question 15

2 adjacent antibody molecules that recognizes the Fc region

Answer 15

IgG CH2 and IgM CH3

Question 16

activates C1s

Answer 16

C1r

Question 17

cleaves C4 and C2 and once activated recognition stage ends

Answer 17

C1s

Question 18

C1q, C1r, C1s are stabilized by?

Answer 18

Calcium

Question 19

C1r and C1s are both?

Answer 19

Serine protease proenzyme (Zymogen)

Question 20

production of C5 convertase

Answer 20

Activation unit (C4, C2, C3)

Question 21

cleaves complement protein C3 into C3a and C3b

Answer 21

C3 convertase

Question 22

anaphylatoxin that causes release of histamine and attracts leukocytes to the site of inflammation

Answer 22

C3a

Question 23

key role in formation of the membrane attack complex

Answer 23

C3b

Question 24

C3b plays a key role in formation of the membrane attack complex which can lead to?

Answer 24

Lysis of target cells

Question 25

proteins that forms a pore on the surface of target cells, leading to their lysis (destruction)

Answer 25

Membrane Attack Complex (MAC)

Question 26

MAC is initiated by the activation of the complement system, which leads to?

Answer 26

Cleavage of C5 into C5a and C5b

Question 27

? binds to C6, C7, C8, and multiple C9 molecules to form the MAC

Answer 27

C5b

Question 28

end product of alternative pathway?

Answer 28

C3bBb

Question 29

pathogens can be destroyed in the absence of antibodies by means of?

Answer 29

Alternative Pathway

Question 30

represents another means of activating complement without antibody being present

Answer 30

Lectin Pathway

Question 31

binds to mannose or related sugars in a calcium dependent manner to initiate this pathway

Answer 31

Mannose Binding Lectin (MBL)

Question 32

considered an acute phase protein because it is produced by the liver and is normally present in serum but increases during initial inflammatory response

Answer 32

Mannose Binding Lectin (MBL)

Question 33

dissociates C1r and C1s from C1q

Answer 33

C1 Inhibitor (C1INH)

Question 34

cleaves c3b and c4b

Answer 34

Factor I

Question 35

principal soluble regulator of alternative pathway; binds to C3b, preventing the binding of factor B

Answer 35

Factor H

Question 36

acts as a cofactor with factor I to inactivate c4b (C4bp)

Answer 36

C4 Binding Protein

Question 37

prevents attachment of C5b67 complex to cell membranes

Answer 37

S Protein (Vitronectin)