IS Major Histocompatibility Complex (MHC)

Question 1

major histocompatibility complex was originally referred to as?

Answer 1

Human Leukocyte Antigen

Question 2

determine whether transplanted tissue is histocompatible and thus accepted or recognized as foreign or rejected

Answer 2

Major Histocompatibility Complex molecules

Question 3

found on all nucleated cells in the body and play a pivotal role of development of both humoral and cellular immunity

Answer 3

Major Histocompatibility Complex

Question 4

most polymorphic system found in humans

Answer 4

Major Histocompatibility Complex system

Question 5

genes coding for MHC molecules are found in?

Answer 5

Chromosome 6

Question 6

encodes glycoproteins expressed on the surface of all nucleated cells and are used for presentation of endogenous peptide antigens to CD8+ T cells. What MHC class is stated?

Answer 6

MHC Class I

Question 7

encodes glycoproteins expressed on APC and are used for presentation of exogenous peptide antigens to CD4+ T cells. What MHC class is stated?

Answer 7

MHC Class II

Question 8

encodes several different proteins with immune functions including complement proteins, cytokines, and tumor necrosis factor. What MHC class is stated?

Answer 8

MHC Class III

Question 9

where is MHC class I located?

Answer 9

HLA-A, HLA-B, HLA-C

Question 10

where is MHC class II located?

Answer 10

HLA-D

Question 11

different forms of genes or alternate forms of gene

Answer 11

Polymorphism

Question 12

> 2103 alleles

Answer 12

HLA-A

Question 13

> 2605 alleles

Answer 13

HLA-B

Question 14

1551 alleles

Answer 14

HLA-C

Question 15

what is MHC Class I composed of?

Answer 15

a chain and b2-macroglobulin

Question 16

how many times is the a chain folded into?

Answer 16

3

Question 17

the binding site of MHC class I is able to hold peptides that are between?

Answer 17

8 and 11 amino acids

Question 18

a3 region reacts with?

Answer 18

CD8 on cytotoxic T cells

Question 19

what is MHC Class II composed of?

Answer 19

Heterodimers consisting of a and b chain

Question 20

the binding site of MHC class II is able to hold peptides that are between?

Answer 20

13-18 amino acids

Question 21

what allows the class II molecules to capture longer peptides that class I molecules?

Answer 21

peptide binding cleft being open

Question 22

b2 region reacts with?

Answer 22

CD4 on helper T cells

Question 23

where are class I molecules synthesized?

Answer 23

rough endoplasmic reticulum

Question 24

if the CD8+ T cell produces cytokines if it recognizes the antigen as being foreign what will happen?

Answer 24

causes lysis of the entire cell

Question 25

class I molecule is an (endogenous or exogenous) pathway of antigen presentation

Answer 25

endogenous

Question 26

class II molecule is an (endogenous or exogenous) pathway of antigen presentation

Answer 26

exogenous

Question 27

where are class II molecules synthesized?

Answer 27

rough endoplasmic reticulum with invariant chain

Question 28

what is being gradually degraded once transported to endosomal compartment called CLIP?

Answer 28

invariant chain or li

Question 29

what is the fragment called when invariant chain is gradually degraded when it is being transported to endosomal compartment?

Answer 29

class II invariant chain peptide or CLIP

Question 30

clinical significance of MHC

Answer 30

tissue transplant, paternity testing, relevance to development of autoimmune diseases