ISBB

Question 1

COMPONENTS OF FIBRIN GLUE

Answer 1

cryoprecipitate (fibrinogen) and topical thrombin

Question 2

Donor deferral, measles (rubeola) vaccination:

Answer 2

2 weeks

Question 3

Providing an antibody with its corresponding antigen under optimal conditions so that the antibody will attach to the antigen, thereby removing the antibody from the serum

Answer 3

ADSORPTION

Question 4

process whereby cells that are coated with antibody are treated in such a manner as to disrupt the bonds between the antigen and antibody

Answer 4

ELUTION

Question 5

simplest type of mutation
Only one nucleotide in the DNA sequence is changed
Includes substitutions, insertions, deletions

Answer 5

POINT MUTATION

Question 6

gene that does not appear to produce a detectable antigen; a silent gene

Answer 6

AMORPH

Question 7

ANTI-A1 LECTIN:

Answer 7

DOLICHOS BIFLORUS

Question 8

ANTI-B LECTIN:

Answer 8

BANDEIRAEA SIMPLICIFOLIA

Question 9

ANTI-H LECTIN:

Answer 9

ULEX EUROPAEUS

Question 10

ANTI-M LECTIN:

Answer 10

IBERIS AMARA

Question 11

ANTI-N LECTIN:

Answer 11

VICIA GRAMINEA

Question 12

phenomenon whereby an antibody reacts more strongly with a red blood cell carrying a double dose (homozygous inheritance of the appropriate gene) than with a red blood cell carrying a single dose (heterozygous inheritance) of an antigen

Answer 12

DOSAGE

Question 13

portion of the antigen molecule that is directly involved in the interaction with the the antibody;ANTIGENIC DETERMINANT

Answer 13

EPITOPE:

Question 14

antigenic characteristic of the red blood cell membrane that is unique to an individual or a related family of individuals and therefore is not commonly found on all cells (usually less than 1% of the population)

Answer 14

PRIVATE ANTIGEN

Question 15

antigen characteristic of the red blood cell membrane found commonly among individuals, usually more than 98% of the population

Answer 15

PUBLIC ANTIGEN

Question 16

small hemorrhagic spot, LARGER THAN PETECHIA, in the skin or mucous membrane, forming a rounded or irregular blue or purplish patch; also known as bruise

Answer 16

Ecchymosis

Question 17

congenital defect of the third and fourth pharyngeal pouches that affects thymic development, leading to a T-cell deficiency. Patients are subject to recurring viral and fungal infections

Answer 17

DiGeorge anomaly

Question 18

dysproteinemia synonymous with gamma heavy-chain disease. This abnormality is characterized by the presence of monoclonal protein composed of the heavy-chain portion of the immunoglobulin molecule.

Answer 18

Franklin’s disease

Question 19

molecule that when coupled to a hapten, makes the hapten capable of stimulating an immune response

Answer 19

CARRIER

Question 20

simple chemical group that can bind to antibody once it is formed but that CANNOT stimulate antibody formation unless tied to a larger carrier molecule

Answer 20

HAPTEN

Question 21

single antigenic determinant. It is functionally the portion of an antigen that combines with an antibody paratope

Answer 21

EPITOPE

Question 22

part of the antibody molecule that makes contact with the antigenic determinant

Answer 22

PARATOPE

Question 23

frequency of positive results obtained in testing a population of individuals who are positive for antibody

Answer 23

SENSITIVITY

Question 24

proportion of negative test results obtained in the population of individuals who actually lack the antibody in question

Answer 24

SPECIFICITY

Question 25

antigens that are expressed in the developing fetus and in rapidly dividing tissue, such as that associated with tumors, but that are absent in normal adult tissue

Answer 25

ONCOFETAL ANTIGENS

Question 26

Plasmapheresis donor, total protein at least

Answer 26

6 g/dL.

Question 27

Packed red blood cells LEAK _______ into the plasma or additive solution of the blood component during storage. Rapid infusion of a large volume of packed red blood cells may put patient populations such as neonates and patients with cardiac, hepatic, or renal dysfunction at risk of developing hyperkalemia. The transient hyperkalemia related to massive transfusion appear to be related to the patient’s acid base balance, ionized calcium levels, and rate of infusion of the packed red blood cells.

Answer 27

POTASSIUM

Question 28

HARMENING • 4th edition: significant is 32 • 5th edition: significant is 16 to 32 • 6th edition: critical titer is 16

Answer 28

Significant Antibody titer in HDN

Question 29

Antibody enhanced by ACIDIFYING THE PATIENT SERUM:

Answer 29

anti-M

Question 30

Most common cause of transfusion reactions:

Answer 30

CLERICAL ERRORS

Question 31

Donor unit SEAL HAS BEEN BROKEN:

Answer 31

DISCARD THE UNIT

Question 32

Noticeable clots in RBC unit:

Answer 32

DO NOT ISSUE THE UNIT, indication of contamination or bacterial growth

Question 33

FIRST STEP in laboratory investigation of transfusion reaction:

Answer 33

CHECK FOR CLERICAL ERRORS

Question 34

SAGM, ADSOL shelf life:

Answer 34

42 days

Question 35

or red blood cells may be performed up to 3 days after the red cell expire

Answer 35

REJUVENATION

Question 36

Preparation of leukopoor RBCs:

Answer 36

filtering, centrifugation and washing

Question 37

Component of choice for vWD:

Answer 37

CRYOPRECIPITATE

Question 38

Transfusion of ______________IS BEST INDICATED for: NEWBORNS with severe infections

Answer 38

BUFFY COAT

Question 39

Test performed on blood that will be transfused to an acidotic or hypoxic infant:

Answer 39

HEMOGLOBIN S

Question 40

CD marker responsible for E-rosette formation between T cells and sheep RBCs:

Answer 40

CD2

Question 41

Joining (J) chain:

Answer 41

IgM and secretory IgA

Question 42

Ig that helps initiate the classical complement pathway:

Answer 42

IgM and IgG

Question 43

Primary immune response:

Answer 43

IgM

Question 44

Highest titer in secondary response:

Answer 44

IgG

Question 45

Immunoglobulin crosslinks mast cells to release histamine:

Answer 45

IgE

Question 46

Substance detected by RPR and VDRL test:

Answer 46

REAGIN

Question 47

Test for HIV infection in infants who are born to HIV-positive mothers:

Answer 47

PCR

Question 48

Best indicator of early acute HBV infection:

Answer 48

HBsAg

Question 49

First antibody detected in serum after infection with HBV:

Answer 49

anti-HBc

Question 50

Blood products are tested for which virus before being transfused to newborns:

Answer 50

CMV

Question 51

Anti-smooth muscle (ASMA) antibodies:

Answer 51

chronic active hepatitis

Question 52

urinary bladder cancer

Answer 52

Nuclear matrix protein

Question 53

most frequently used animal is the RABBIT followed by goat, pig, sheep, horse, guinea pig and others

Answer 53

POLYCLONAL ANTIBODIES

Question 54

MONOCLONAL ANTIBODIES

Answer 54

MICE