James’ Questions

Question 1

Pyridostigmine MOA

Answer 1

Acetylcholinesterase inhibitor

Question 2

HLA associated with coeliac disease

Answer 2

DQ2 + DQ8

Question 3

Anti-GAD antibodies - what does it stand for and associated with which disease

Answer 3

Antibodies to glutamic acid decarboxylase (anti-GAD) - associated with T1DM

Question 4

Vigabatrin MOA

Answer 4

Inhibits GABA transaminase

Question 5

Site of CSF production

Answer 5

Choroid plexus

Question 6

Adenosine MOA

Answer 6

Reduces conduction time in the AV node by induces potassium efflux and inhibiting calcium influx, so leading to hyperpolarisation and increased threshold for calcium dependent action potentials

Question 7

Clindamycin MOA

Answer 7

Inhibits bacterial protein synthesis at the 50S ribosome

Question 8

S/E vincristine

Answer 8

Peripheral neuropathy

Question 9

S/E methotrexate

Answer 9

Pulmonary fibrosis

Question 10

S/E Dexamethasone

Answer 10

Glycosuria

Question 11

Rituximab MOA

Answer 11

Monoclonal Antibody for CD20

Question 12

Which cells secrete trypsinogen

Answer 12

Acinar cells of the pancreas

Question 13

Which cells secrete alpha 1 anti trypsin

Answer 13

Lungs and liver

Question 14

Which cells secrete ALP

Answer 14

Cholangiocytes

Question 15

Montelukast MOA

Answer 15

Leukotriene receptor antagonist

Question 16

Inhaled nitric oxide MOA

Answer 16

Increases cyclic GMP levels

Question 17

Zidovudine MOA

Answer 17

Inhibitor of HIV 1 reverse transcriptase

Question 18

Eye problem caused by pituitary adenoma

Answer 18

Bitemporal hemianopia

Question 19

Most common cause of RPD

Answer 19

PUJ obstruction

Question 20

Genomic imprinting definition

Answer 20

One copy of the inherited gene is suppressed

Question 21

Leptin place of release

Answer 21

Adipose tissue

Question 22

Where is ghrelin released

Answer 22

Stomach

Question 23

Where is so atrophic released

Answer 23

Anterior pituitary

Question 24

Metformin MOA

Answer 24

Decreases gluconeogenesis
Improves insulin sensitivity

Question 25

IGF-1 site of action

Answer 25

Tyrosine kinase receptor

Question 26

Mantoux - hypersensitivity type

Answer 26

Type IV

Question 27

Atomoxetine MOA

Answer 27

Used in ADHA - NE reuptake blocker

Question 28

ECG s/e of Clarithromycin

Answer 28

Prolonged QT

Question 29

Effect of ionising radiation on cells

Answer 29

Chromosomal aberrations

Question 30

MCAD deficiency test

Answer 30

Acyl carnitine

Question 31

What happens to the body in non-REM sleep

Answer 31

Increased muscle tone

Question 32

Cause of anaemia in prematurity

Answer 32

Low EPO

Question 33

How does parvovirus cause anaemia

Answer 33

Cessation of erythrocyte production

Question 34

How to confirm brain stem death in a newborn

Answer 34

Disconnect ventilator and see if they are breathing with the CO2

Question 35

Contents of plasmalyte

Answer 35

140 mmol Na 5 mmol K 1.5 mmol Mg 98 mmol Cl 27 mmol acetate 23 mmol gluconate