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Peds > Junkins - Infectious Disease > Flashcards

Junkins - Infectious Disease Flashcards

1
Q

Complement deficiencies in infants that are Greater in alternative pathway than in the classic pathway

A

Complement deficiency

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2
Q

Early onset Neonatal Sepsis (EONS) is how old?

A

< 6 days old

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3
Q

Late Onset Neonatal Sepsis (LONS) is how old?

A

6 days to 3 mos old

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4
Q

Bacteria that cause neonatal sepsis

A
    1. E. COLI
      1. Group B Strep
      2. Listeria

-also S. aureus and coagulase-negative staph

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5
Q

Bacitracin resistant and causes neonatal sepsis

A

Group B Strep (GBS)

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6
Q

Tx is Penicillin G
or empiric treatment with Ampicillin and Gentamicin

(or 3rd generation cephalosporin)

A

Group B Strep

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7
Q

Only gram-positive organism to produce endotoxin

A

Listeria monocytogenes

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8
Q

Tx:

First line regimen is Ampicillin

Synergize with Gentamicin for CNS infection

Causes endocarditis in neonates

A

Listeria

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9
Q

Tx is Vancomycin

A

Coagulase-negative Staphylococcus

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10
Q

Purple grapes (clusters) and coagulase negative on slide

A

Coagulase-negative staph

*see slide 34

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11
Q

Diagnosis is by the isolation of spores from the stool and confirmed by identification of the toxin in stool samples

A

Clostridium botulinum

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12
Q

Produces a preformed, heat-labile toxin that inhibits Ach release at the neuromuscular junction

A

Clostridium botulinum

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13
Q

Antitoxin therapy includes human-derived botulism immune globulin and is used for infants less than one year old (who ingested honey)

A

C. botulinum treatment

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14
Q

High Yield:

Both are gram-positive cocci

A

Strep and Staph

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15
Q

High Yield:

Gram positive cocci in CHAINS

A

Strep

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16
Q

High Yield:

Gram positive cocci in CLUSTERS

A

Staph

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17
Q

High Yield:

Test that helps differentiate strep from staph

A

Catalase test

18
Q

High Yield:

Test to differentiate members of the genus Staphylococcus

A

Coagulase test

19
Q

High Yield:

  • CATALASE NEGATIVE
  • Gram positive cocci
A

Strep

20
Q

German measles

A

Rubella

21
Q
  • Beta hemolytic
  • Bacitracin sensitive
  • PYR positive
A

Group A Strep

22
Q

“Measles” measles

A

Rubeola

23
Q

M12 (M-protein) strains associated with acute glomerulonephritis (via immune complexes

A

Group A strep

24
Q

Labs: Anti-Streptolysin O (ASO) titers

A

Group A strep

25
Q

Causes impetigo

A

Group A strep and S. aureus

26
Q

Inhibits G alpha proteins; ultimately results in accumulation of cAMP

A

A subunit of B. Pertussis exotoxin

over-activates

27
Q
  • Gram-positive diplococci
  • Encapsulated
  • IgA protease
  • Lancet-shaped
A

Streptococcus pneumoniae

28
Q

13 serotypes cause invasive pneumonia

A

Strep. Pneumoniae

*13 valent vaccine

29
Q

One of the most common causes of infant and toddler diarrhea in US

A

Rotavirus

30
Q

Most common bacterial cause of pneumonia in children less than and more than 5 yrs old

A

S. Pneumoniae

31
Q

Commonly causes inflammatory diarrhea in people less than one year old

A

Campylobacter jejuni

32
Q

The magnitude of the neonate’s ability to generate immunoglobulin is initially (increased/decreased)

A

Decreased

33
Q

IgM levels are low are high at birth?

A

low

34
Q

Most common cause of infant pneumonia

A

S. Pneumoniae

35
Q

Complement deficiencies in infants are greater in the alternative or classic pathway?

A

Alternative

36
Q

Neonates are deficient in these components of the complement cascade that lead to killing of organisms, especially gram-negative bacteria.

A

Terminal cytotoxic components

37
Q

Compared to adults, neonates have a lower and less effective storage pool of these white blood cells

A

Neutrophils

38
Q

Organisms causing late onset neonatal sepsis

A

Coagulase-negative Staphylococcus

Staphylococcus aureus

39
Q

Mnemonic to identify gram positive cocci

A

On the office’s “staph” retreat, there was NO StRESs

  • First Aid Step 1, 2015
40
Q

What age group is very susceptible to sepsis?

A

Neonates

41
Q

CAMP factor + test

A

Group B Strep

Peds (13 decks)

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