KACH: Antiemetic Drugs

Question 1

When neausa and vomiting are due to stimulation of vestibular receptors use these medications

Answer 1

Antihistamines & Anticholinergic

Question 2

Antiemetics work

Locally

Centrally

Answer 2

Locally: decrease local response being sent to the medulla to induce vomiting

Centrally: blocks the chemoreceptor trigger zone CTZ or suppresses the vomiting center directly

Question 3

Chlorpromazine (generic)
Perphenazine
Prochlorperazine
Promethazine

Class of medication
Use

Answer 3

Phenothiazines

Treats neausa/ V Post Op

Have a psychotic effect too

Question 4

Promethazine has this indication

Answer 4

N/V

Motion sickness

Question 5

Phenothiazines are central acting antiemetics that change responsiveness or stimulation of the ______ in the medulla

Answer 5

CTZ

Question 6

Indications

N/V associated with Anesthesia
Intractable Hiccups

Answer 6

Phenothiazines

Question 7

Contradictions

Don’t use in patients with brain damage due to further risk of CNS depression

Answer 7

Phenothiazines (Promethazine) -Zine

Question 8

Adverse Effects

HypoTNS
Cardiac arrhythmias

Dry mouth

Tardive dyskinesia

Neuroleptic malignant syndrome

Photosensitivty

Urine: pink - red-brown

Answer 8

Phenothiazines (Promethazine) -zine

Question 9

Treats

N/V associated with emetogenic cancer chemotherapy, radiation

Post op N/V

Action: blocks receptor sites associated with N/V peripheral & in the CTZ

Answer 9

5- HT³

Question 10

Granisetron
Ondansetron
Palonosetron

This type of drug

Indications

Answer 10

5 HT³ Receptor Blocker

Treatment of N/V associated with chemotherapy

Question 11

These drugs act directly on CNS to block N/V but have little to no effect in the serotonin, dopamine, or corticosteroids receptors

Answer 11

Substance P/Neurokinin 1 receptor Antagonist

Question 12

Aprepitant
Fosaprepitant
Dimeglumine

Rolapitant

Work on CNS but have little affect on serotonin, dopamine, corticosteroids

Answer 12

Substance P/Neurokinin 1 receptor Antagonist

Question 13

These type of Antiemetics have the adverse effects of

Neutropenia
Anemia
Leukopenia

Answer 13

Substance P / Neurokinin 1 receptor Antagonist

Question 14

Aprepitant & fosaprepitant (Substance P / Neurokinin receptor Antagonist)

Have this adverse effects

Answer 14

Decrease effectiveness of hormonal birth control

Question 15

Substance P/Neurokinin receptor Antagonist

Have restrictions on combination

Rolapitant cannot be combined with thioridazine or pimozide

Aprepitant & fosaprepitant should not be used with pimozide

T / F

Answer 15

T

Question 16

There is a decreased effectiveness in ____ if it is combin3d with aprepitant or fosaprepitant (Substance P/ Neurokinin receptor Antagonist)

Answer 16

Warfarin

Question 17

Dimenhydrinate, hydroxyzine , meclizine are this type of antiemetics

Answer 17

Antihistamines

Associated with motion sickness

Question 18

Dronabinol & nabilone are this type of antiemetics

Answer 18

cannabidoids

Question 19

Scopolamine if this type of antiemetics

Answer 19

Anticholinergic

Question 20

(-Pitant) / Dimeglumine are Substance P/ Neurokinin receptor Antagonist

Have which effect on the body?

Answer 20

Antiemetics

Work in CNS but don’t have an effect on Serotonin & Dopamine Levels

Question 21

Granisetron
Ondansetron
Palonosetron

5 HT³ Receptor Antagonist are used for N/V associated with…

Answer 21

Chemotherapy